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The delta isoform of phosphatidylinositol-3-kinase predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib.
Villaume MT, Arrate MP, Ramsey HE, Sunthankar KI, Jenkins MT, Moyo TK, Smith BN, Fischer MA, Childress MA, Gorska AE, Ferrell PB, Savona MR. Villaume MT, et al. Among authors: savona mr. Exp Hematol. 2021 May;97:57-65.e5. doi: 10.1016/j.exphem.2021.02.008. Epub 2021 Feb 19. Exp Hematol. 2021. PMID: 33617893 Free PMC article.
Germline risk of clonal haematopoiesis.
Silver AJ, Bick AG, Savona MR. Silver AJ, et al. Among authors: savona mr. Nat Rev Genet. 2021 Sep;22(9):603-617. doi: 10.1038/s41576-021-00356-6. Epub 2021 May 13. Nat Rev Genet. 2021. PMID: 33986496 Free PMC article. Review.
Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation.
Ramsey HE, Stengel K, Pino JC, Johnston G, Childress M, Gorska AE, Arrate PM, Fuller L, Villaume M, Fischer MA, Ferrell PB Jr, Roe CE, Zou J, Lubbock ALR, Stubbs M, Zinkel S, Irish JM, Lopez CF, Hiebert S, Savona MR. Ramsey HE, et al. Among authors: savona mr. Target Oncol. 2021 Sep;16(5):663-674. doi: 10.1007/s11523-021-00830-5. Epub 2021 Jul 29. Target Oncol. 2021. PMID: 34324169 Free PMC article.
Publisher Correction: Germline risk of clonal haematopoiesis.
Silver AJ, Bick AG, Savona MR. Silver AJ, et al. Among authors: savona mr. Nat Rev Genet. 2021 Sep;22(9):619. doi: 10.1038/s41576-021-00384-2. Nat Rev Genet. 2021. PMID: 34140664 Free PMC article. No abstract available.
141 results