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MALDI imaging mass spectrometry visualizes the distribution of antidepressant duloxetine and its major metabolites in mouse brain, liver, kidney, and spleen tissues.
Khalil SM, Qin X, Hakenjos JM, Wang J, Hu Z, Liu X, Wang J, Maletic-Savatic M, MacKenzie KR, Matzuk MM, Li F. Khalil SM, et al. Among authors: li f. Drug Metab Dispos. 2024 Apr 24:DMD-AR-2024-001719. doi: 10.1124/dmd.124.001719. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38658163 Free article.
Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1.
Holmes S, Jain P, Rodriguez KG, Williams J, Yu Z, Cerda-Smith C, Samuel ELG, Campbell J, Hakenjos JM, Monsivais D, Li F, Chamakuri S, Matzuk MM, Santini C, MacKenzie KR, Young DW. Holmes S, et al. Among authors: li f. ACS Med Chem Lett. 2024 Jan 2;15(1):107-115. doi: 10.1021/acsmedchemlett.3c00464. eCollection 2024 Jan 11. ACS Med Chem Lett. 2024. PMID: 38229743 Free PMC article.
DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors.
Jimmidi R, Chamakuri S, Lu S, Ucisik MN, Chen PJ, Bohren KM, Moghadasi SA, Versteeg L, Nnabuife C, Li JY, Qin X, Chen YC, Faver JC, Nyshadham P, Sharma KL, Sankaran B, Judge A, Yu Z, Li F, Pollet J, Harris RS, Matzuk MM, Palzkill T, Young DW. Jimmidi R, et al. Among authors: li jy, li f. Commun Chem. 2023 Aug 4;6(1):164. doi: 10.1038/s42004-023-00961-y. Commun Chem. 2023. PMID: 37542196 Free PMC article.
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