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Physiologically based pharmacokinetic modeling to predict the impact of liver cirrhosis on glucuronidation via UGT1A4 & UGT2B7/2B4 - a case study with midazolam.
Ozbey AC, Keemink J, Wagner B, Pugliano A, Krähenbühl S, Annaert P, Fowler S, Parrott N, Umehara K. Ozbey AC, et al. Among authors: umehara k. Drug Metab Dispos. 2024 Apr 23:DMD-AR-2023-001635. doi: 10.1124/dmd.123.001635. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38653501 Free article.
Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam.
Fowler S, Brink A, Cleary Y, Günther A, Heinig K, Husser C, Kletzl H, Kratochwil N, Mueller L, Savage M, Stillhart C, Tuerck D, Ullah M, Umehara K, Poirier A. Fowler S, et al. Among authors: umehara k. Drug Metab Dispos. 2022 Jan;50(1):65-75. doi: 10.1124/dmd.121.000563. Epub 2021 Oct 7. Drug Metab Dispos. 2022. PMID: 34620695 Review.
270 results