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Physiologically based pharmacokinetic modeling to predict the impact of liver cirrhosis on glucuronidation via UGT1A4 & UGT2B7/2B4 - a case study with midazolam.
Drug Metab Dispos. 2024 Apr 23:DMD-AR-2023-001635. doi: 10.1124/dmd.123.001635. Online ahead of print.
Drug Metab Dispos. 2024.
PMID: 38653501
Free article.
PBPK Modelling for Drugs Cleared by Non-CYP Enzymes: State-of-the-Art and Future Perspectives.
Ozbey AC, Fowler S, Leys K, Annaert P, Umehara K, Parrott N.
Ozbey AC, et al.
Drug Metab Dispos. 2023 Oct 25:DMD-AR-2023-001487. doi: 10.1124/dmd.123.001487. Online ahead of print.
Drug Metab Dispos. 2023.
PMID: 37879848
Free article.
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Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding.
Van der Veken M, Brouwers J, Ozbey AC, Umehara K, Stillhart C, Knops N, Augustijns P, Parrott NJ.
Van der Veken M, et al. Among authors: ozbey ac.
Pharmaceutics. 2023 Aug 29;15(9):2231. doi: 10.3390/pharmaceutics15092231.
Pharmaceutics. 2023.
PMID: 37765200
Free PMC article.
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Assessment of in vitro antimicrobial activity of clindamycin metabolites against Staphylococcus species.
Van De Sijpe G, Mylemans M, Armengol Álvarez L, Ozbey AC, Allegaert K, Rozenski J, Annaert P, Desmet S, Spriet I.
Van De Sijpe G, et al. Among authors: ozbey ac.
Clin Microbiol Infect. 2023 Oct;29(10):1345-1347. doi: 10.1016/j.cmi.2023.07.005. Epub 2023 Jul 6.
Clin Microbiol Infect. 2023.
PMID: 37422078
No abstract available.
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The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis.
Duthaler U, Bachmann F, Ozbey AC, Umehara K, Parrott N, Fowler S, Krähenbühl S.
Duthaler U, et al. Among authors: ozbey ac.
Clin Pharmacokinet. 2023 Aug;62(8):1141-1155. doi: 10.1007/s40262-023-01261-3. Epub 2023 Jun 16.
Clin Pharmacokinet. 2023.
PMID: 37328712
Free PMC article.
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Dose Adjustment in Patients with Liver Cirrhosis - Comparison of Two Different Modeling Approaches.
Ozbey AC, Bachmann F, Duthaler U, Annaert P, Fowler S, Umehara K, Parrott N, Krähenbühl S.
Ozbey AC, et al.
Clin Pharmacol Ther. 2023 Jun;113(6):1346-1358. doi: 10.1002/cpt.2897. Epub 2023 Apr 20.
Clin Pharmacol Ther. 2023.
PMID: 37017611
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Population Pharmacokinetic Analysis of Pazopanib in Patients and Determination of Target AUC.
Ozbey AC, Combarel D, Poinsignon V, Lovera C, Saada E, Mir O, Paci A.
Ozbey AC, et al.
Pharmaceuticals (Basel). 2021 Sep 15;14(9):927. doi: 10.3390/ph14090927.
Pharmaceuticals (Basel). 2021.
PMID: 34577627
Free PMC article.
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