Sahani RL - Search Results

1

Synthesis of Chiral 1,2-Amino Alcohol-Containing Compounds Utilizing Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Unprotected α-Ketoamines.

Mangunuru HPR, Terrab L, Janganati V, Kalikinidi NR, Tenneti S, Natarajan V, Shada ADR, Naini SR, Gajula P, Lee D, Samankumara LP, Mamunooru M, Jayaraman A, Sahani RL, Yin J, Hewa-Rahinduwage CC, Gangu A, Chen A, Wang Z, Desai B, Yue TY, Wannere CS, Armstrong JD 3rd, Donsbach KO, Sirasani G, Gupton BF, Qu B, Senanayake CH. Mangunuru HPR, et al. Among authors: sahani rl. J Org Chem. 2024 May 3;89(9):6085-6099. doi: 10.1021/acs.joc.4c00045. Epub 2024 Apr 22. J Org Chem. 2024. PMID: 38648720

2

Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV).

Senaweera S, Edwards TC, Kankanala J, Wang Y, Sahani RL, Xie J, Geraghty RJ, Wang Z. Senaweera S, et al. Among authors: sahani rl. Acta Pharm Sin B. 2022 Apr;12(4):1671-1684. doi: 10.1016/j.apsb.2021.08.019. Epub 2021 Aug 23. Acta Pharm Sin B. 2022. PMID: 35847513 Free PMC article.

3

Potency and metabolic stability: a molecular hybrid case in the design of novel PF74-like small molecules targeting HIV-1 capsid protein.

Sahani RL, Akther T, Cilento ME, Castaner AE, Zhang H, Kirby KA, Xie J, Sarafianos SG, Wang Z. Sahani RL, et al. RSC Med Chem. 2021 Sep 28;12(12):2031-2044. doi: 10.1039/d1md00292a. eCollection 2021 Dec 15. RSC Med Chem. 2021. PMID: 35028563 Free PMC article.

4

Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex.

Wang L, Edwards TC, Sahani RL, Xie J, Aihara H, Geraghty RJ, Wang Z. Wang L, et al. Among authors: sahani rl. Eur J Med Chem. 2021 Oct 15;222:113640. doi: 10.1016/j.ejmech.2021.113640. Epub 2021 Jun 12. Eur J Med Chem. 2021. PMID: 34147908 Free PMC article.

5

Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74.

Sahani RL, Diana-Rivero R, Vernekar SKV, Wang L, Du H, Zhang H, Castaner AE, Casey MC, Kirby KA, Tedbury PR, Xie J, Sarafianos SG, Wang Z. Sahani RL, et al. Viruses. 2021 Mar 15;13(3):479. doi: 10.3390/v13030479. Viruses. 2021. PMID: 33804121 Free PMC article.

6

Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability.

Wang L, Casey MC, Vernekar SKV, Sahani RL, Kirby KA, Du H, Zhang H, Tedbury PR, Xie J, Sarafianos SG, Wang Z. Wang L, et al. Among authors: sahani rl. Acta Pharm Sin B. 2021 Mar;11(3):810-822. doi: 10.1016/j.apsb.2020.07.016. Epub 2020 Jul 31. Acta Pharm Sin B. 2021. PMID: 33777683 Free PMC article.

7

Novel HIV-1 capsid-targeting small molecules of the PF74 binding site.

Wang L, Casey MC, Vernekar SKV, Sahani RL, Kankanala J, Kirby KA, Du H, Hachiya A, Zhang H, Tedbury PR, Xie J, Sarafianos SG, Wang Z. Wang L, et al. Among authors: sahani rl. Eur J Med Chem. 2020 Oct 15;204:112626. doi: 10.1016/j.ejmech.2020.112626. Epub 2020 Jul 19. Eur J Med Chem. 2020. PMID: 32814250 Free PMC article.

8

Nitrene Transfer and Carbene Transfer in Gold Catalysis.

Ye LW, Zhu XQ, Sahani RL, Xu Y, Qian PC, Liu RS. Ye LW, et al. Among authors: sahani rl. Chem Rev. 2021 Jul 28;121(14):9039-9112. doi: 10.1021/acs.chemrev.0c00348. Epub 2020 Aug 3. Chem Rev. 2021. PMID: 32786423

9

Chemical profiling of HIV-1 capsid-targeting antiviral PF74.

Wang L, Casey MC, Vernekar SKV, Do HT, Sahani RL, Kirby KA, Du H, Hachiya A, Zhang H, Tedbury PR, Xie J, Sarafianos SG, Wang Z. Wang L, et al. Among authors: sahani rl. Eur J Med Chem. 2020 Aug 15;200:112427. doi: 10.1016/j.ejmech.2020.112427. Epub 2020 May 12. Eur J Med Chem. 2020. PMID: 32438252 Free PMC article.

10

Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules.

Vernekar SKV, Sahani RL, Casey MC, Kankanala J, Wang L, Kirby KA, Du H, Zhang H, Tedbury PR, Xie J, Sarafianos SG, Wang Z. Vernekar SKV, et al. Among authors: sahani rl. Viruses. 2020 Apr 16;12(4):452. doi: 10.3390/v12040452. Viruses. 2020. PMID: 32316297 Free PMC article.

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