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Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles.
J Med Chem. 2024 May 9;67(9):7406-7430. doi: 10.1021/acs.jmedchem.4c00239. Epub 2024 Apr 20.
J Med Chem. 2024.
PMID: 38642371
Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma.
Tawfik HO, Saleh MM, Ammara A, Khaleel EF, Badi R, Khater YTT, Rasheed RA, Attia AA, Hefny SM, Elkaeed EB, Nocentini A, Supuran CT, Eldehna WM, Shaldam MA.
Tawfik HO, et al. Among authors: hefny sm.
J Med Chem. 2024 Jan 25;67(2):1611-1623. doi: 10.1021/acs.jmedchem.3c02279. Epub 2024 Jan 11.
J Med Chem. 2024.
PMID: 38207099
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A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments.
Hefny SM, El-Moselhy TF, El-Din N, Ammara A, Angeli A, Ferraroni M, El-Dessouki AM, Shaldam MA, Yahya G, Al-Karmalawy AA, Supuran CT, Tawfik HO.
Hefny SM, et al.
Eur J Med Chem. 2024 May 24;274:116527. doi: 10.1016/j.ejmech.2024.116527. Online ahead of print.
Eur J Med Chem. 2024.
PMID: 38810335
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Role of fetal echocardiography in the evaluation of structure and function of fetal heart in diabetic pregnancies.
Fouda UM, Abou ElKassem MM, Hefny SM, Fouda RM, Hashem AT.
Fouda UM, et al. Among authors: hefny sm.
J Matern Fetal Neonatal Med. 2013 Apr;26(6):571-5. doi: 10.3109/14767058.2012.743521. Epub 2012 Nov 29.
J Matern Fetal Neonatal Med. 2013.
PMID: 23176302
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