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Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs.
Rosado-Quiñones AM, Colón-Lorenzo EE, Pala ZR, Bosch J, Kudyba K, Kudyba H, Leed SE, Roncal N, Baerga-Ortiz A, Roche-Lima A, Gerena Y, Fidock DA, Roth A, Vega-Rodríguez J, Serrano AE. Rosado-Quiñones AM, et al. Among authors: pala zr. Antimicrob Agents Chemother. 2024 Apr 19:e0164323. doi: 10.1128/aac.01643-23. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 38639491 Free article.
Anopheles salivary apyrase regulates blood meal hemostasis and drives malaria parasite transmission.
Pala ZR, Alves E Silva TL, Minai M, Crews B, Patino-Martinez E, Carmona-Rivera C, Valenzuela-Leon PC, Martin-Martin I, Flores-Garcia Y, Cachau RE, Srivastava N, Moore IN, Alves DA, Kaplan MJ, Fischer E, Calvo E, Vega-Rodriguez J. Pala ZR, et al. bioRxiv [Preprint]. 2023 May 22:2023.05.22.541827. doi: 10.1101/2023.05.22.541827. bioRxiv. 2023. PMID: 37292610 Free PMC article. Preprint.
Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission.
Pascini TV, Jeong YJ, Huang W, Pala ZR, Sá JM, Wells MB, Kizito C, Sweeney B, Alves E Silva TL, Andrew DJ, Jacobs-Lorena M, Vega-Rodríguez J. Pascini TV, et al. Among authors: pala zr. Nat Commun. 2022 May 26;13(1):2949. doi: 10.1038/s41467-022-30606-y. Nat Commun. 2022. PMID: 35618711 Free PMC article.
The fibrinolytic system enables the onset of Plasmodium infection in the mosquito vector and the mammalian host.
Alves E Silva TL, Radtke A, Balaban A, Pascini TV, Pala ZR, Roth A, Alvarenga PH, Jeong YJ, Olivas J, Ghosh AK, Bui H, Pybus BS, Sinnis P, Jacobs-Lorena M, Vega-Rodríguez J. Alves E Silva TL, et al. Among authors: pala zr. Sci Adv. 2021 Feb 5;7(6):eabe3362. doi: 10.1126/sciadv.abe3362. Print 2021 Feb. Sci Adv. 2021. PMID: 33547079 Free PMC article.
13 results