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Safety and efficacy of losmapimod in facioscapulohumeral muscular dystrophy (ReDUX4): a randomised, double-blind, placebo-controlled phase 2b trial.
Tawil R, Wagner KR, Hamel JI, Leung DG, Statland JM, Wang LH, Genge A, Sacconi S, Lochmüller H, Reyes-Leiva D, Diaz-Manera J, Alonso-Perez J, Muelas N, Vilchez JJ, Pestronk A, Gibson S, Goyal NA, Hayward LJ, Johnson N, LoRusso S, Freimer M, Shieh PB, Subramony SH, van Engelen B, Kools J, Leinhard OD, Widholm P, Morabito C, Moxham CM, Cadavid D, Mellion ML, Odueyungbo A, Tracewell WG, Accorsi A, Ronco L, Gould RJ, Shoskes J, Rojas LA, Jiang JG. Tawil R, et al. Among authors: wang lh. Lancet Neurol. 2024 May;23(5):477-486. doi: 10.1016/S1474-4422(24)00073-5. Lancet Neurol. 2024. PMID: 38631764 Clinical Trial.
Facioscapulohumeral Dystrophy.
Wang LH, Tawil R. Wang LH, et al. Curr Neurol Neurosci Rep. 2016 Jul;16(7):66. doi: 10.1007/s11910-016-0667-0. Curr Neurol Neurosci Rep. 2016. PMID: 27215221 Review.
Current Therapeutic Approaches in FSHD.
Wang LH, Tawil R. Wang LH, et al. J Neuromuscul Dis. 2021;8(3):441-451. doi: 10.3233/JND-200554. J Neuromuscul Dis. 2021. PMID: 33579868 Free PMC article. Review.
Quantitative muscle analysis in facioscapulohumeral muscular dystrophy using whole-body fat-referenced MRI: Protocol development, multicenter feasibility, and repeatability.
Widholm P, Ahlgren A, Karlsson M, Romu T, Tawil R, Wagner KR, Statland JM, Wang LH, Shieh PB, van Engelen BGM, Cadavid D, Ronco L, Odueyungbo AO, Jiang JG, Mellion ML, Dahlqvist Leinhard O. Widholm P, et al. Among authors: wang lh. Muscle Nerve. 2022 Aug;66(2):183-192. doi: 10.1002/mus.27638. Epub 2022 Jun 11. Muscle Nerve. 2022. PMID: 35585766
Quantitative Muscle Analysis in FSHD Using Whole-Body Fat-Referenced MRI: Composite Scores for Longitudinal and Cross-sectional Analysis.
Mellion ML, Widholm P, Karlsson M, Ahlgren A, Tawil R, Wagner KR, Statland JM, Wang L, Shieh PB, van Engelen BGM, Kools J, Ronco L, Odueyungbo A, Jiang J, Han JJ, Hatch M, Towles J, Leinhard OD, Cadavid D. Mellion ML, et al. Neurology. 2022 Aug 30;99(9):e877-e889. doi: 10.1212/WNL.0000000000200757. Epub 2022 Jun 24. Neurology. 2022. PMID: 35750498
Clinical trial readiness to solve barriers to drug development in FSHD (ReSolve): protocol of a large, international, multi-center prospective study.
LoRusso S, Johnson NE, McDermott MP, Eichinger K, Butterfield RJ, Carraro E, Higgs K, Lewis L, Mul K, Sacconi S, Sansone VA, Shieh P, van Engelen B, Wagner K, Wang L, Statland JM, Tawil R; ReSolve Investigators and the FSHD CTRN18. LoRusso S, et al. BMC Neurol. 2019 Sep 10;19(1):224. doi: 10.1186/s12883-019-1452-x. BMC Neurol. 2019. PMID: 31506080 Free PMC article.
Longitudinal measures of RNA expression and disease activity in FSHD muscle biopsies.
Wong CJ, Wang LH, Friedman SD, Shaw D, Campbell AE, Budech CB, Lewis LM, Lemmers RJFL, Statland JM, van der Maarel SM, Tawil RN, Tapscott SJ. Wong CJ, et al. Among authors: wang lh. Hum Mol Genet. 2020 Apr 15;29(6):1030-1043. doi: 10.1093/hmg/ddaa031. Hum Mol Genet. 2020. PMID: 32083293 Free PMC article.
Elevated plasma complement components in facioscapulohumeral dystrophy.
Wong CJ, Wang L, Holers VM, Frazer-Abel A, van der Maarel SM, Tawil R, Statland JM, Tapscott SJ; ReSolve Network. Wong CJ, et al. Hum Mol Genet. 2022 Jun 4;31(11):1821-1829. doi: 10.1093/hmg/ddab364. Hum Mol Genet. 2022. PMID: 34919696 Free PMC article.
Lean tissue mass measurements by dual-energy X-ray absorptiometry and associations with strength and functional outcome measures in facioscapulohumeral muscular dystrophy.
Wang LH, Leung DG, Wagner KR, Lowry SJ, McDermott MP, Eichinger K, Higgs K, Walker M, Lewis L, Martens WB, Mul K, Sansone VA, Shieh P, Elsheikh B, LoRusso S, Butterfield RJ, Johnson N, Preston MR, Messina C, Carraro E, Tawil R, Statland J; ReSolve Investigators of the FSHD CTRN. Wang LH, et al. Neuromuscul Disord. 2023 Sep;33(9):63-68. doi: 10.1016/j.nmd.2023.06.008. Epub 2023 Jun 21. Neuromuscul Disord. 2023. PMID: 37400350
1,978 results