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"3G" Trial: An RNA Editing Signature to Guide Gastric Cancer Chemotherapy.
An O, Song Y, Ke X, So JB, Sundar R, Yang H, Rha SY, Lee MH, Tay ST, Ong X, Tan ALK, Ng MCH, Tantoso E, Chen L, Tan P, Yong WP; Singapore Gastric Cancer Consortium (SGCC). An O, et al. Among authors: chen l. Cancer Res. 2021 May 15;81(10):2788-2798. doi: 10.1158/0008-5472.CAN-20-2872. Epub 2021 Feb 8. Cancer Res. 2021. PMID: 33558338
Pan-cancer pervasive upregulation of 3' UTR splicing drives tumourigenesis.
Chan JJ, Zhang B, Chew XH, Salhi A, Kwok ZH, Lim CY, Desi N, Subramaniam N, Siemens A, Kinanti T, Ong S, Sanchez-Mejias A, Ly PT, An O, Sundar R, Fan X, Wang S, Siew BE, Lee KC, Chong CS, Lieske B, Cheong WK, Goh Y, Fam WN, Ooi MG, Koh BTH, Iyer SG, Ling WH, Chen J, Yoong BK, Chanwat R, Bonney GK, Goh BKP, Zhai W, Fullwood MJ, Wang W, Tan KK, Chng WJ, Dan YY, Pitt JJ, Roca X, Guccione E, Vardy LA, Chen L, Gao X, Chow PKH, Yang H, Tay Y. Chan JJ, et al. Among authors: chen j, chen l. Nat Cell Biol. 2022 Jun;24(6):928-939. doi: 10.1038/s41556-022-00913-z. Epub 2022 May 26. Nat Cell Biol. 2022. PMID: 35618746 Free PMC article.
p53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain).
Teoh PJ, An O, Chung TH, Vaiyapuri T, Raju A, Hoppe MM, Toh SHM, Wang W, Chan MC, Fullwood MJ, Jeyasekharan AD, Tergaonkar V, Chen L, Yang H, Chng WJ. Teoh PJ, et al. Among authors: chen l. Oncogene. 2022 Apr;41(14):2106-2121. doi: 10.1038/s41388-022-02227-8. Epub 2022 Feb 21. Oncogene. 2022. PMID: 35190641
Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer.
Tay DJT, Song Y, Peng B, Toh TB, Hooi L, Toh DK, Hong H, Tang SJ, Han J, Gan WL, Chan THM, Krishna MS, Patil KM, Maraswami M, Loh TP, Dan YY, Zhou L, Bonney GK, Chow PK, Chen G, Chow EK, Le MTN, Chen L. Tay DJT, et al. Among authors: chen l, chen g. Mol Ther. 2021 Nov 3;29(11):3258-3273. doi: 10.1016/j.ymthe.2021.05.008. Epub 2021 May 8. Mol Ther. 2021. PMID: 33974998 Free PMC article.
Pseudogene-mediated DNA demethylation leads to oncogene activation.
Kwon J, Liu YV, Gao C, Bassal MA, Jones AI, Yang J, Chen Z, Li Y, Yang H, Chen L, Di Ruscio A, Tay Y, Chai L, Tenen DG. Kwon J, et al. Among authors: chen z, chen l. Sci Adv. 2021 Oct;7(40):eabg1695. doi: 10.1126/sciadv.abg1695. Epub 2021 Oct 1. Sci Adv. 2021. PMID: 34597139 Free PMC article.
RNA editome imbalance in hepatocellular carcinoma.
Qi L, Chan TH, Tenen DG, Chen L. Qi L, et al. Among authors: chen l. Cancer Res. 2014 Mar 1;74(5):1301-6. doi: 10.1158/0008-5472.CAN-13-3485. Epub 2014 Feb 20. Cancer Res. 2014. PMID: 24556721 Review.
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