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Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling.
Fields JK, Gyllenbäck EJ, Bogacz M, Obi J, Birkedal GS, Sjöström K, Maravillas K, Grönberg C, Rattik S, Kihn K, Flowers M, Smith AK, Hansen N, Fioretos T, Huyhn C, Liberg D, Deredge D, Sundberg EJ. Fields JK, et al. Among authors: gronberg c. Cell Rep. 2024 Apr 11:114099. doi: 10.1016/j.celrep.2024.114099. Online ahead of print. Cell Rep. 2024. PMID: 38636519 Free article.
Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosis.
Grönberg C, Rattik S, Tran-Manh C, Zhou X, Rius Rigau A, Li YN, Györfi AH, Dickel N, Kunz M, Kreuter A, Matei EA, Zhu H, Skoog P, Liberg D, Distler JH, Trinh-Minh T. Grönberg C, et al. Ann Rheum Dis. 2024 Apr 9:ard-2023-225158. doi: 10.1136/ard-2023-225158. Online ahead of print. Ann Rheum Dis. 2024. PMID: 38594058 Free article.
Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation.
Mulholland M, Depuydt MAC, Jakobsson G, Ljungcrantz I, Grentzmann A, To F, Bengtsson E, Jaensson Gyllenbäck E, Grönberg C, Rattik S, Liberg D, Schiopu A, Björkbacka H, Kuiper J, Bot I, Slütter B, Engelbertsen D. Mulholland M, et al. Among authors: gronberg c. Cardiovasc Res. 2024 May 7;120(6):581-595. doi: 10.1093/cvr/cvae046. Cardiovasc Res. 2024. PMID: 38563353 Free PMC article.
Structural basis of ion uptake in copper-transporting P1B-type ATPases.
Salustros N, Grønberg C, Abeyrathna NS, Lyu P, Orädd F, Wang K, Andersson M, Meloni G, Gourdon P. Salustros N, et al. Among authors: gronberg c. Nat Commun. 2022 Aug 31;13(1):5121. doi: 10.1038/s41467-022-32751-w. Nat Commun. 2022. PMID: 36045128 Free PMC article.
Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy.
Rydberg Millrud C, Deronic A, Grönberg C, Jaensson Gyllenbäck E, von Wachenfeldt K, Forsberg G, Liberg D. Rydberg Millrud C, et al. Among authors: gronberg c. Cancer Immunol Immunother. 2023 Mar;72(3):667-678. doi: 10.1007/s00262-022-03277-3. Epub 2022 Aug 29. Cancer Immunol Immunother. 2023. PMID: 36036818 Free PMC article.
The two-domain elevator-type mechanism of zinc-transporting ZIP proteins.
Wiuf A, Steffen JH, Becares ER, Grønberg C, Mahato DR, Rasmussen SGF, Andersson M, Croll T, Gotfryd K, Gourdon P. Wiuf A, et al. Among authors: gronberg c. Sci Adv. 2022 Jul 15;8(28):eabn4331. doi: 10.1126/sciadv.abn4331. Epub 2022 Jul 13. Sci Adv. 2022. PMID: 35857505 Free PMC article.
Structure and ion-release mechanism of PIB-4-type ATPases.
Grønberg C, Hu Q, Mahato DR, Longhin E, Salustros N, Duelli A, Lyu P, Bågenholm V, Eriksson J, Rao KU, Henderson DI, Meloni G, Andersson M, Croll T, Godaly G, Wang K, Gourdon P. Grønberg C, et al. Elife. 2021 Dec 24;10:e73124. doi: 10.7554/eLife.73124. Elife. 2021. PMID: 34951590 Free PMC article.
Structure and transport mechanism of P5B-ATPases.
Li P, Wang K, Salustros N, Grønberg C, Gourdon P. Li P, et al. Among authors: gronberg c. Nat Commun. 2021 Jun 25;12(1):3973. doi: 10.1038/s41467-021-24148-y. Nat Commun. 2021. PMID: 34172751 Free PMC article.
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