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High incidence of imperforate vagina in ADGRA3-deficient mice.
Kvam JM, Nybo ML, Torz L, Sustarsic RK, Jensen KHR, Nielsen JE, Frederiksen H, Gadgaard S, Spiess K, Poulsen SS, Thomsen JS, Cowin P, Blomberg Jensen M, Kurita T, Rosenkilde MM. Kvam JM, et al. Among authors: gadgaard s. BMC Biol. 2024 Apr 8;22(1):77. doi: 10.1186/s12915-024-01873-6. BMC Biol. 2024. PMID: 38589878 Free PMC article.
Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.
Nybo ML, Kvam JM, Nielsen JE, Frederiksen H, Spiess K, Jensen KHR, Gadgaard S, Walser ALS, Thomsen JS, Cowin P, Juul A, Blomberg Jensen M, Rosenkilde MM. Nybo ML, et al. Among authors: gadgaard s. FASEB J. 2023 Feb;37(2):e22781. doi: 10.1096/fj.202200762RR. FASEB J. 2023. PMID: 36688818 Free PMC article.
GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment.
Gabe MBN, Skov-Jeppesen K, Gasbjerg LS, Schiellerup SP, Martinussen C, Gadgaard S, Boer GA, Oeke J, Torz LJ, Veedfald S, Svane MS, Bojsen-Møller KN, Madsbad S, Holst JJ, Hartmann B, Rosenkilde MM. Gabe MBN, et al. Among authors: gadgaard s. Pharmacol Res. 2022 Feb;176:106058. doi: 10.1016/j.phrs.2022.106058. Epub 2022 Jan 4. Pharmacol Res. 2022. PMID: 34995796 Clinical Trial.
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.
Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW. Sun W, et al. Among authors: gadgaard s. Cell Res. 2020 Dec;30(12):1098-1108. doi: 10.1038/s41422-020-00442-0. Epub 2020 Nov 25. Cell Res. 2020. PMID: 33239759 Free PMC article.
Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system.
Gabe MBN, van der Velden WJC, Gadgaard S, Smit FX, Hartmann B, Bräuner-Osborne H, Rosenkilde MM. Gabe MBN, et al. Among authors: gadgaard s. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):122-132. doi: 10.1111/bcpt.13289. Epub 2019 Aug 19. Basic Clin Pharmacol Toxicol. 2020. PMID: 31299132 Free PMC article.