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Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells.
Picco G, Rao Y, Al Saedi A, Lee Y, Vieira SF, Bhosle S, May K, Herranz-Ors C, Walker SJ, Shenje R, Dincer C, Gibson F, Banerjee R, Hewitson Z, Werner T, Cottom JE, Peng Y, Deng N, Landis P, Conticelli D, McCarten K, Bush J, Sharma M, Lightfoot H, House D, Milford E, Grant EK, Glogowski MP, Wagner CD, Bantscheff M, Rutkowska-Klute A, Network Uk Group CM, Zappacosta F, Pettinger J, Barthorpe S, Eberl HC, Jones BT, Schneck JL, Murphy DJ, Voest EE, Taygerly JP, DeMartino MP, Coelho MA, Houseley J, Sharma G, Schwartz BJ, Garnett MJ. Picco G, et al. Among authors: house d. Cancer Discov. 2024 Apr 9. doi: 10.1158/2159-8290.CD-24-0052. Online ahead of print. Cancer Discov. 2024. PMID: 38587317
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments.
Aatkar A, Vuorinen A, Longfield OE, Gilbert K, Peltier-Heap R, Wagner CD, Zappacosta F, Rittinger K, Chung CW, House D, Tomkinson NCO, Bush JT. Aatkar A, et al. Among authors: house d. ACS Chem Biol. 2023 Sep 15;18(9):1926-1937. doi: 10.1021/acschembio.3c00034. Epub 2023 Apr 21. ACS Chem Biol. 2023. PMID: 37084287 Free PMC article.
A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein Ligands.
Grant EK, Fallon DJ, Hann MM, Fantom KGM, Quinn C, Zappacosta F, Annan RS, Chung CW, Bamborough P, Dixon DP, Stacey P, House D, Patel VK, Tomkinson NCO, Bush JT. Grant EK, et al. Among authors: house d. Angew Chem Int Ed Engl. 2020 Nov 16;59(47):21096-21105. doi: 10.1002/anie.202008361. Epub 2020 Sep 7. Angew Chem Int Ed Engl. 2020. PMID: 32745361 Free article.
Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
Biggadike K, Bledsoe RK, Coe DM, Cooper TW, House D, Iannone MA, Macdonald SJ, Madauss KP, McLay IM, Shipley TJ, Taylor SJ, Tran TB, Uings IJ, Weller V, Williams SP. Biggadike K, et al. Among authors: house d. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18114-9. doi: 10.1073/pnas.0909125106. Epub 2009 Oct 12. Proc Natl Acad Sci U S A. 2009. PMID: 19822747 Free PMC article.
Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.
Juss JK, House D, Amour A, Begg M, Herre J, Storisteanu DM, Hoenderdos K, Bradley G, Lennon M, Summers C, Hessel EM, Condliffe A, Chilvers ER. Juss JK, et al. Among authors: house d. Am J Respir Crit Care Med. 2016 Oct 15;194(8):961-973. doi: 10.1164/rccm.201509-1818OC. Am J Respir Crit Care Med. 2016. PMID: 27064380 Free PMC article.
263 results