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Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism.
Jekhmane S, Derks MGN, Maity S, Slingerland CJ, Tehrani KHME, Medeiros-Silva J, Charitou V, Ammerlaan D, Fetz C, Consoli NA, Cochrane RVK, Matheson EJ, van der Weijde M, Elenbaas BOW, Lavore F, Cox R, Lorent JH, Baldus M, Künzler M, Lelli M, Cochrane SA, Martin NI, Roos WH, Breukink E, Weingarth M. Jekhmane S, et al. Among authors: weingarth m. Nat Microbiol. 2024 May 23. doi: 10.1038/s41564-024-01696-9. Online ahead of print. Nat Microbiol. 2024. PMID: 38783023
A Resistance-Evading Antibiotic for Treating Anthrax.
Hughes D, Lawrence W, Peel J, Rosan W, Ling L, Niiti N, Aaron P, Shukla R, MacGillavry H, Heine H, Martha H, Elbert W, Weingarth M, Lewis K. Hughes D, et al. Among authors: weingarth m. Res Sq [Preprint]. 2024 Mar 25:rs.3.rs-3991430. doi: 10.21203/rs.3.rs-3991430/v1. Res Sq. 2024. PMID: 38585816 Free PMC article. Preprint.
An antibiotic from an uncultured bacterium binds to an immutable target.
Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, De Benedetti S, Krueger AM, Vermeulen BJA, Harbig T, Lavore F, Kumar R, Honorato RV, Grein F, Nieselt K, Liu Y, Bonvin AMJJ, Baldus M, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. Shukla R, et al. Among authors: weingarth m. Cell. 2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Epub 2023 Aug 22. Cell. 2023. PMID: 37611581 Free article.
A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance.
van der Krift F, Zijlmans DW, Shukla R, Javed A, Koukos PI, Schwarz LL, Timmermans-Sprang EP, Maas PE, Gahtory D, van den Nieuwboer M, Mol JA, Strous GJ, Bonvin AM, van der Stelt M, Veldhuizen EJ, Weingarth M, Vermeulen M, Klumperman J, Maurice MM. van der Krift F, et al. Among authors: weingarth m. Life Sci Alliance. 2023 Aug 17;6(11):e202302058. doi: 10.26508/lsa.202302058. Print 2023 Nov. Life Sci Alliance. 2023. PMID: 37591722 Free PMC article.
A new antibiotic from an uncultured bacterium binds to an immutable target.
Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, de Benedetti S, Krueger AM, Vermeulen BJA, Lavore F, Honorato RV, Grein F, Bonvin A, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. Shukla R, et al. Among authors: weingarth m. bioRxiv [Preprint]. 2023 May 15:2023.05.15.540765. doi: 10.1101/2023.05.15.540765. bioRxiv. 2023. PMID: 37292624 Free PMC article. Updated. Preprint.
Specific Lipid Studies in Complex Membranes by Solid-State NMR Spectroscopy.
van Beekveld RAM, Derks MGN, Kumar R, Smid L, Maass T, Medeiros-Silva J, Breukink E, Weingarth M. van Beekveld RAM, et al. Among authors: weingarth m. Chemistry. 2022 Dec 15;28(70):e202202472. doi: 10.1002/chem.202202472. Epub 2022 Oct 25. Chemistry. 2022. PMID: 36098094 Free PMC article.
59 results