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Linking triphenylphosphonium cation to a bicyclic hydroquinone improves their antiplatelet effect via the regulation of mitochondrial function.
Redox Biol. 2024 Jun;72:103142. doi: 10.1016/j.redox.2024.103142. Epub 2024 Apr 1.
Redox Biol. 2024.
PMID: 38581860
Free PMC article.
Assessing mitochondria-targeted acyl hydroquinones on the mitochondrial platelet function and cytotoxic activity: Role of the linker length.
Montecino-Garrido H, Sepúlveda M, Méndez D, Monroy-Cárdenas M, Alfaro S, González-Avendaño M, Caballero J, Urra FA, Araya-Maturana R, Fuentes E.
Montecino-Garrido H, et al.
Free Radic Biol Med. 2023 Nov 1;208:26-36. doi: 10.1016/j.freeradbiomed.2023.07.030. Epub 2023 Jul 27.
Free Radic Biol Med. 2023.
PMID: 37516371
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In Vitro Effect of Mitochondria-Targeted Triphenylphosphonium-Based Compounds (Honokiol, Lonidamine, and Atovaquone) on the Platelet Function and Cytotoxic Activity.
Montecino-Garrido H, Méndez D, Araya-Maturana R, Millas-Vargas JP, Wehinger S, Fuentes E.
Montecino-Garrido H, et al.
Front Pharmacol. 2022 May 11;13:893873. doi: 10.3389/fphar.2022.893873. eCollection 2022.
Front Pharmacol. 2022.
PMID: 35645840
Free PMC article.
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