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Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
Boshoff HIM, Young K, Ahn YM, Yadav VD, Crowley BM, Yang L, Su J, Oh S, Arora K, Andrews J, Manikkam M, Sutphin M, Smith AJ, Weiner DM, Piazza MK, Fleegle JD, Gomez F, Dayao EK, Prideaux B, Zimmerman M, Kaya F, Sarathy J, Tan VY, Via LE, Tschirret-Guth R, Lenaerts AJ, Robertson GT, Dartois V, Olsen DB, Barry CE 3rd. Boshoff HIM, et al. Among authors: weiner dm. ACS Infect Dis. 2024 May 10;10(5):1679-1695. doi: 10.1021/acsinfecdis.4c00025. Epub 2024 Apr 6. ACS Infect Dis. 2024. PMID: 38581700
Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives.
Via LE, Savic R, Weiner DM, Zimmerman MD, Prideaux B, Irwin SM, Lyon E, O'Brien P, Gopal P, Eum S, Lee M, Lanoix JP, Dutta NK, Shim T, Cho JS, Kim W, Karakousis PC, Lenaerts A, Nuermberger E, Barry CE 3rd, Dartois V. Via LE, et al. Among authors: weiner dm. ACS Infect Dis. 2015 May 8;1(5):203-214. doi: 10.1021/id500028m. ACS Infect Dis. 2015. PMID: 26086040 Free PMC article.
The association between sterilizing activity and drug distribution into tuberculosis lesions.
Prideaux B, Via LE, Zimmerman MD, Eum S, Sarathy J, O'Brien P, Chen C, Kaya F, Weiner DM, Chen PY, Song T, Lee M, Shim TS, Cho JS, Kim W, Cho SN, Olivier KN, Barry CE 3rd, Dartois V. Prideaux B, et al. Among authors: weiner dm. Nat Med. 2015 Oct;21(10):1223-7. doi: 10.1038/nm.3937. Epub 2015 Sep 7. Nat Med. 2015. PMID: 26343800 Free PMC article.
Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum.
Sarathy JP, Via LE, Weiner D, Blanc L, Boshoff H, Eugenin EA, Barry CE 3rd, Dartois VA. Sarathy JP, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e02266-17. doi: 10.1128/AAC.02266-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29203492 Free PMC article.
Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N, Olsen DB, Goodwin M, Sutphin M, Weiner DM, Via LE, Boshoff HIM, Barry CE 3rd. Oh S, et al. Among authors: weiner dm. J Med Chem. 2018 Nov 21;61(22):9952-9965. doi: 10.1021/acs.jmedchem.8b00883. Epub 2018 Nov 5. J Med Chem. 2018. PMID: 30350998 Free PMC article.
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.
Beites T, O'Brien K, Tiwari D, Engelhart CA, Walters S, Andrews J, Yang HJ, Sutphen ML, Weiner DM, Dayao EK, Zimmerman M, Prideaux B, Desai PV, Masquelin T, Via LE, Dartois V, Boshoff HI, Barry CE 3rd, Ehrt S, Schnappinger D. Beites T, et al. Among authors: weiner dm. Nat Commun. 2019 Oct 31;10(1):4970. doi: 10.1038/s41467-019-12956-2. Nat Commun. 2019. PMID: 31672993 Free PMC article.
A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study.
Kaya F, Ernest JP, LoMauro K, Gengenbacher M, Madani A, Aragaw WW, Zimmerman MD, Sarathy JP, Alvarez N, Daudelin I, Wang H, Lanni F, Weiner DM, Via LE, Barry CE 3rd, Olivier KN, Dick T, Podell BK, Savic RM, Dartois V. Kaya F, et al. Among authors: weiner dm. Antimicrob Agents Chemother. 2022 Mar 15;66(3):e0221221. doi: 10.1128/aac.02212-21. Epub 2022 Jan 31. Antimicrob Agents Chemother. 2022. PMID: 35099272 Free PMC article.
88 results