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Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.
Lü Y, Cho T, Mukherjee S, Suarez CF, Gonzalez-Foutel NS, Malik A, Martinez S, Dervovic D, Oh RH, Langille E, Al-Zahrani KN, Hoeg L, Lin ZY, Tsai R, Mbamalu G, Rotter V, Ashton-Prolla P, Moffat J, Chemes LB, Gingras AC, Oren M, Durocher D, Schramek D. Lü Y, et al. Among authors: lin zy. Mol Syst Biol. 2024 Apr 5. doi: 10.1038/s44320-024-00032-x. Online ahead of print. Mol Syst Biol. 2024. PMID: 38580884 Free article.
Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens.
Zhao Y, Tabet D, Rubio Contreras D, Lao L, Kousholt AN, Weile J, Melo H, Hoeg L, Feng S, Coté AG, Lin ZY, Setiaputra D, Jonkers J, Gingras AC, Gómez Herreros F, Roth FP, Durocher D. Zhao Y, et al. Among authors: lin zy. Mol Cell. 2023 Aug 3;83(15):2792-2809.e9. doi: 10.1016/j.molcel.2023.06.025. Epub 2023 Jul 20. Mol Cell. 2023. PMID: 37478847 Free article.
HELB Is a Feedback Inhibitor of DNA End Resection.
Tkáč J, Xu G, Adhikary H, Young JTF, Gallo D, Escribano-Díaz C, Krietsch J, Orthwein A, Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Borst P, Brown GW, Gingras AC, Rottenberg S, Masson JY, Durocher D. Tkáč J, et al. Among authors: lin zy. Mol Cell. 2016 Feb 4;61(3):405-418. doi: 10.1016/j.molcel.2015.12.013. Epub 2016 Jan 7. Mol Cell. 2016. PMID: 26774285 Free article.
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux.
Masud SN, Chandrashekhar M, Aregger M, Tan G, Zhang X, Mero P, Pirman DA, Zaslaver O, Smolen GA, Lin ZY, Wong CJ, Boone C, Gingras AC, Montenegro-Burke JR, Moffat J. Masud SN, et al. Among authors: lin zy. Nat Chem Biol. 2022 Dec;18(12):1370-1379. doi: 10.1038/s41589-022-01109-0. Epub 2022 Aug 15. Nat Chem Biol. 2022. PMID: 35970996
787 results