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In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Holland CJ, MacLachlan BJ, Bianchi V, Hesketh SJ, Morgan R, Vickery O, Bulek AM, Fuller A, Godkin A, Sewell AK, Rizkallah PJ, Wells S, Cole DK. Holland CJ, et al. Among authors: maclachlan bj. Front Immunol. 2018 Apr 11;9:674. doi: 10.3389/fimmu.2018.00674. eCollection 2018. Front Immunol. 2018. PMID: 29696015 Free PMC article.
Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.
MacLachlan BJ, Dolton G, Papakyriakou A, Greenshields-Watson A, Mason GH, Schauenburg A, Besneux M, Szomolay B, Elliott T, Sewell AK, Gallimore A, Rizkallah P, Cole DK, Godkin A. MacLachlan BJ, et al. J Biol Chem. 2019 Dec 27;294(52):20246-20258. doi: 10.1074/jbc.RA119.009437. Epub 2019 Oct 16. J Biol Chem. 2019. PMID: 31619516 Free PMC article.
CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features.
Greenshields-Watson A, Attaf M, MacLachlan BJ, Whalley T, Rius C, Wall A, Lloyd A, Hughes H, Strange KE, Mason GH, Schauenburg AJ, Hulin-Curtis SL, Geary J, Chen Y, Lauder SN, Smart K, Vijaykrishna D, Grau ML, Shugay M, Andrews R, Dolton G, Rizkallah PJ, Gallimore AM, Sewell AK, Godkin AJ, Cole DK. Greenshields-Watson A, et al. Among authors: maclachlan bj. Cell Rep. 2020 Jul 14;32(2):107885. doi: 10.1016/j.celrep.2020.107885. Cell Rep. 2020. PMID: 32668259 Free PMC article.
Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy.
Crean RM, MacLachlan BJ, Madura F, Whalley T, Rizkallah PJ, Holland CJ, McMurran C, Harper S, Godkin A, Sewell AK, Pudney CR, van der Kamp MW, Cole DK. Crean RM, et al. Among authors: maclachlan bj. Mol Ther Oncolytics. 2020 Jul 31;18:443-456. doi: 10.1016/j.omto.2020.07.008. eCollection 2020 Sep 25. Mol Ther Oncolytics. 2020. PMID: 32913893 Free PMC article.
A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.
Hulin-Curtis S, Geary JK, MacLachlan BJ, Altmann DM, Baillon L, Cole DK, Greenshields-Watson A, Hesketh SJ, Humphreys IR, Jones IM, Lauder SN, Mason GH, Smart K, Scourfield DO, Scott J, Sukhova K, Stanton RJ, Wall A, Rizkallah PJ, Barclay WS, Gallimore A, Godkin A. Hulin-Curtis S, et al. Among authors: maclachlan bj. Cell Rep. 2024 May 30;43(6):114259. doi: 10.1016/j.celrep.2024.114259. Online ahead of print. Cell Rep. 2024. PMID: 38819988 Free article.
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