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Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts.
Yabo YA, Moreno-Sanchez PM, Pires-Afonso Y, Kaoma T, Nosirov B, Scafidi A, Ermini L, Lipsa A, Oudin A, Kyriakis D, Grzyb K, Poovathingal SK, Poli A, Muller A, Toth R, Klink B, Berchem G, Berthold C, Hertel F, Mittelbronn M, Heiland DH, Skupin A, Nazarov PV, Niclou SP, Michelucci A, Golebiewska A. Yabo YA, et al. Among authors: klink b. Genome Med. 2024 Apr 2;16(1):51. doi: 10.1186/s13073-024-01321-8. Genome Med. 2024. PMID: 38566128 Free PMC article.
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
Golebiewska A, Hau AC, Oudin A, Stieber D, Yabo YA, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Neirinckx V, Muller A, Kaoma T, Nazarov PV, Azuaje F, De Falco A, Flies B, Richart L, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Malta TM, Noushmehr H, Kwon YJ, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R, Niclou SP. Golebiewska A, et al. Among authors: klink b. Acta Neuropathol. 2020 Dec;140(6):919-949. doi: 10.1007/s00401-020-02226-7. Epub 2020 Oct 3. Acta Neuropathol. 2020. PMID: 33009951 Free PMC article.
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts.
Yabo YA, Moreno-Sanchez PM, Pires-Afonso Y, Kaoma T, Nosirov B, Scafidi A, Ermini L, Lipsa A, Oudin A, Kyriakis D, Grzyb K, Poovathingal SK, Poli A, Muller A, Toth R, Klink B, Berchem G, Berthold C, Hertel F, Mittelbronn M, Heiland DH, Skupin A, Nazarov PV, Niclou SP, Michelucci A, Golebiewska A. Yabo YA, et al. Among authors: klink b. bioRxiv [Preprint]. 2023 Dec 12:2023.03.05.531162. doi: 10.1101/2023.03.05.531162. bioRxiv. 2023. PMID: 36945572 Free PMC article. Updated. Preprint.
AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.
Schuster A, Klein E, Neirinckx V, Knudsen AM, Fabian C, Hau AC, Dieterle M, Oudin A, Nazarov PV, Golebiewska A, Muller A, Perez-Hernandez D, Rodius S, Dittmar G, Bjerkvig R, Herold-Mende C, Klink B, Kristensen BW, Niclou SP. Schuster A, et al. Among authors: klink b. Nat Commun. 2020 Dec 11;11(1):6366. doi: 10.1038/s41467-020-20029-y. Nat Commun. 2020. PMID: 33311477 Free PMC article.
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.
Sharma AB, Erasimus H, Pinto L, Caron MC, Gopaul D, Peterlini T, Neumann K, Nazarov PV, Fritah S, Klink B, Herold-Mende CC, Niclou SP, Pasero P, Calsou P, Masson JY, Britton S, Van Dyck E. Sharma AB, et al. Among authors: klink b. Nucleic Acids Res. 2021 Sep 27;49(17):9906-9925. doi: 10.1093/nar/gkab785. Nucleic Acids Res. 2021. PMID: 34500463 Free PMC article.
Pericytes/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma.
Mäder L, Blank AE, Capper D, Jansong J, Baumgarten P, Wirsik NM, Zachskorn C, Ehlers J, Seifert M, Klink B, Liebner S, Niclou S, Naumann U, Harter PN, Mittelbronn M. Mäder L, et al. Among authors: klink b. Oncotarget. 2018 May 8;9(35):24041-24053. doi: 10.18632/oncotarget.25275. eCollection 2018 May 8. Oncotarget. 2018. PMID: 29844871 Free PMC article.
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
Klink B, Miletic H, Stieber D, Huszthy PC, Campos Valenzuela JA, Balss J, Wang J, Schubert M, Sakariassen PØ, Sundstrøm T, Torsvik A, Aarhus M, Mahesparan R, von Deimling A, Kaderali L, Niclou SP, Schröck E, Bjerkvig R, Nigro JM. Klink B, et al. PLoS One. 2013;8(3):e59773. doi: 10.1371/journal.pone.0059773. Epub 2013 Mar 19. PLoS One. 2013. PMID: 23527265 Free PMC article.
CASP9 germline mutation in a family with multiple brain tumors.
Ronellenfitsch MW, Oh JE, Satomi K, Sumi K, Harter PN, Steinbach JP, Felsberg J, Capper D, Voegele C, Durand G, McKay J, Le Calvez-Kelm F, Schittenhelm J, Klink B, Mittelbronn M, Ohgaki H. Ronellenfitsch MW, et al. Among authors: klink b. Brain Pathol. 2018 Jan;28(1):94-102. doi: 10.1111/bpa.12471. Epub 2017 Apr 17. Brain Pathol. 2018. PMID: 27935156 Free PMC article.
130 results