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Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau.
Wachter A, Woodbury ME, Lombardo S, Abdourahman A, Wuest C, McGlame E, Pastika T, Tamm J, Romanul N, Yanamandra K, Bennett R, Lin G, Kwon T, Liao F, Klein C, Grinberg Y, Jaisa-Aad M, Li H, Frosch MP, Kummer MP, Das S, Dellovade T, Karran EH, Langlois X, Ried JS, Serrano-Pozo A, Talanian RV, Biber K, Hyman BT. Wachter A, et al. Among authors: langlois x. Acta Neuropathol. 2024 Apr 1;147(1):65. doi: 10.1007/s00401-024-02704-2. Acta Neuropathol. 2024. PMID: 38557897 Free PMC article.
Common mouse models of tauopathy reflect early but not late human disease.
Wenger K, Viode A, Schlaffner CN, van Zalm P, Cheng L, Dellovade T, Langlois X, Bannon A, Chang R, Connors TR, Oakley D, Renard B, Rappsilber J, Hyman B, Steen H, Steen JA. Wenger K, et al. Among authors: langlois x. Mol Neurodegener. 2023 Feb 2;18(1):10. doi: 10.1186/s13024-023-00601-y. Mol Neurodegener. 2023. PMID: 36732784 Free PMC article.
Evaluation of Small-Animal PET Outcome Measures to Detect Disease Modification Induced by BACE Inhibition in a Transgenic Mouse Model of Alzheimer Disease.
Deleye S, Waldron AM, Verhaeghe J, Bottelbergs A, Wyffels L, Van Broeck B, Langlois X, Schmidt M, Stroobants S, Staelens S. Deleye S, et al. Among authors: langlois x. J Nucl Med. 2017 Dec;58(12):1977-1983. doi: 10.2967/jnumed.116.187625. Epub 2017 Jun 13. J Nucl Med. 2017. PMID: 28611242 Free article.
Preclinical Evaluation of 18F-JNJ64349311, a Novel PET Tracer for Tau Imaging.
Declercq L, Rombouts F, Koole M, Fierens K, Mariën J, Langlois X, Andrés JI, Schmidt M, Macdonald G, Moechars D, Vanduffel W, Tousseyn T, Vandenberghe R, Van Laere K, Verbruggen A, Bormans G. Declercq L, et al. Among authors: langlois x. J Nucl Med. 2017 Jun;58(6):975-981. doi: 10.2967/jnumed.116.185199. Epub 2017 Feb 23. J Nucl Med. 2017. PMID: 28232614 Free article.
Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease.
Rombouts FJ, Andrés JI, Ariza M, Alonso JM, Austin N, Bottelbergs A, Chen L, Chupakhin V, Cleiren E, Fierens K, Fontana A, Langlois X, Leenaerts JE, Mariën J, Martínez Lamenca C, Salter R, Schmidt ME, Te Riele P, Wintmolders C, Trabanco AA, Zhang W, Macdonald G, Moechars D. Rombouts FJ, et al. Among authors: langlois x. J Med Chem. 2017 Feb 23;60(4):1272-1291. doi: 10.1021/acs.jmedchem.6b01173. Epub 2017 Feb 10. J Med Chem. 2017. PMID: 28106992
96 results