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Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau.
Wachter A, Woodbury ME, Lombardo S, Abdourahman A, Wuest C, McGlame E, Pastika T, Tamm J, Romanul N, Yanamandra K, Bennett R, Lin G, Kwon T, Liao F, Klein C, Grinberg Y, Jaisa-Aad M, Li H, Frosch MP, Kummer MP, Das S, Dellovade T, Karran EH, Langlois X, Ried JS, Serrano-Pozo A, Talanian RV, Biber K, Hyman BT. Wachter A, et al. Among authors: frosch mp. Acta Neuropathol. 2024 Apr 1;147(1):65. doi: 10.1007/s00401-024-02704-2. Acta Neuropathol. 2024. PMID: 38557897 Free PMC article.
Sex-specific genetic predictors of Alzheimer's disease biomarkers.
Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetics Consortium (ADGC); Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ. Deming Y, et al. Acta Neuropathol. 2018 Dec;136(6):857-872. doi: 10.1007/s00401-018-1881-4. Epub 2018 Jul 2. Acta Neuropathol. 2018. PMID: 29967939 Free PMC article.
Altered localization of nucleoporin 98 in primary tauopathies.
Dickson JR, Frosch MP, Hyman BT. Dickson JR, et al. Among authors: frosch mp. Brain Commun. 2022 Dec 22;5(1):fcac334. doi: 10.1093/braincomms/fcac334. eCollection 2023. Brain Commun. 2022. PMID: 36601621 Free PMC article.
Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics.
Wang Z, Jin M, Hong W, Liu W, Reczek D, Lagomarsino VN, Hu Y, Weeden T, Frosch MP, Young-Pearse TL, Pradier L, Selkoe D, Walsh DM. Wang Z, et al. Among authors: frosch mp. Acta Neuropathol Commun. 2023 Mar 10;11(1):39. doi: 10.1186/s40478-023-01511-2. Acta Neuropathol Commun. 2023. PMID: 36899414 Free PMC article.
Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment.
Kivisäkk P, Carlyle BC, Sweeney T, Trombetta BA, LaCasse K, El-Mufti L, Tuncali I, Chibnik LB, Das S, Scherzer CR, Johnson KA, Dickerson BC, Gomez-Isla T, Blacker D, Oakley DH, Frosch MP, Hyman BT, Aghvanyan A, Bathala P, Campbell C, Sigal G, Stengelin M, Arnold SE. Kivisäkk P, et al. Among authors: frosch mp. Front Neurol. 2023 Mar 2;14:1069411. doi: 10.3389/fneur.2023.1069411. eCollection 2023. Front Neurol. 2023. PMID: 36937522 Free PMC article.
Reply: Soluble oligomers or insoluble fibrils?
Mate de Gerando A, Quittot N, Frosch MP, Hyman BT. Mate de Gerando A, et al. Among authors: frosch mp. Acta Neuropathol. 2023 Dec;146(6):863-866. doi: 10.1007/s00401-023-02634-5. Epub 2023 Sep 21. Acta Neuropathol. 2023. PMID: 37733036 Free PMC article. No abstract available.
Head-to-head comparison of [18F]-Flortaucipir, [18F]-MK-6240 and [18F]-PI-2620 postmortem binding across the spectrum of neurodegenerative diseases.
Aguero C, Dhaynaut M, Amaral AC, Moon SH, Neelamegam R, Scapellato M, Carazo-Casas C, Kumar S, El Fakhri G, Johnson K, Frosch MP, Normandin MD, Gómez-Isla T. Aguero C, et al. Among authors: frosch mp. Acta Neuropathol. 2024 Jan 27;147(1):25. doi: 10.1007/s00401-023-02672-z. Acta Neuropathol. 2024. PMID: 38280071 Free PMC article.
Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis.
Nicks R, Clement NF, Alvarez VE, Tripodis Y, Baucom ZH, Huber BR, Mez J, Alosco ML, Aytan N, Cherry JD, Cormier KA, Kubilius C, Mathias R, Svirsky SE, Pothast MJ, Hildebrandt AM, Chung J, Han X, Crary JF, McKee AC, Frosch MP, Stein TD. Nicks R, et al. Among authors: frosch mp. Acta Neuropathol. 2023 Apr;145(4):395-408. doi: 10.1007/s00401-023-02539-3. Epub 2023 Jan 21. Acta Neuropathol. 2023. PMID: 36681782
360 results