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Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase.
Clay WK, Buck AK, He Y, Hernández Sánchez DN, Ward NA, Lear JM, Nguyen KQ, Clark BH, Sapia RJ, Lalisse RF, Sriraman A, Cadieux CL, McElroy CA, Callam CS, Hadad CM. Clay WK, et al. Among authors: hadad cm. Chem Res Toxicol. 2024 Apr 15;37(4):643-657. doi: 10.1021/acs.chemrestox.4c00024. Epub 2024 Mar 31. Chem Res Toxicol. 2024. PMID: 38556765
Study of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase.
Yoder RJ, Zhuang Q, Beck JM, Franjesevic A, Blanton TG, Sillart S, Secor T, Guerra L, Brown JD, Reid C, McElroy CA, Doğan Ekici Ö, Callam CS, Hadad CM. Yoder RJ, et al. Among authors: hadad cm. ACS Med Chem Lett. 2017 May 8;8(6):622-627. doi: 10.1021/acsmedchemlett.7b00037. eCollection 2017 Jun 8. ACS Med Chem Lett. 2017. PMID: 28626522 Free PMC article.
Demonstration of In Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents.
Zhuang Q, Franjesevic AJ, Corrigan TS, Coldren WH, Dicken R, Sillart S, DeYong A, Yoshino N, Smith J, Fabry S, Fitzpatrick K, Blanton TG, Joseph J, Yoder RJ, McElroy CA, Ekici ÖD, Callam CS, Hadad CM. Zhuang Q, et al. Among authors: hadad cm. J Med Chem. 2018 Aug 23;61(16):7034-7042. doi: 10.1021/acs.jmedchem.7b01620. Epub 2018 Jun 20. J Med Chem. 2018. PMID: 29870665
Corrigendum to: "A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin".
McGarry KG, Lalisse RF, Moyer RA, Johnson KM, Tallan AM, Winters TP, Taris JE, McElroy CA, Lemmon EE, Shafaat HS, Fan Y, Deal A, Marguet SC, Harvilchuck JA, Hadad CM, Wood DW. McGarry KG, et al. Among authors: hadad cm. Toxicol Sci. 2020 Sep 1;177(1):300. doi: 10.1093/toxsci/kfaa057. Toxicol Sci. 2020. PMID: 32458003 No abstract available.
189 results