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Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Dhavale DD, Barclay AM, Borcik CG, Basore K, Berthold DA, Gordon IR, Liu J, Milchberg MH, O'Shea JY, Rau MJ, Smith Z, Sen S, Summers B, Smith J, Warmuth OA, Perrin RJ, Perlmutter JS, Chen Q, Fitzpatrick JAJ, Schwieters CD, Tajkhorshid E, Rienstra CM, Kotzbauer PT. Dhavale DD, et al. Among authors: o shea jy. Nat Commun. 2024 Mar 29;15(1):2750. doi: 10.1038/s41467-024-46832-5. Nat Commun. 2024. PMID: 38553463 Free PMC article.
Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Dhavale DD, Barclay AM, Borcik CG, Basore K, Gordon IR, Liu J, Milchberg MH, O'shea J, Rau MJ, Smith Z, Sen S, Summers B, Smith J, Warmuth OA, Chen Q, Fitzpatrick JAJ, Schwieters CD, Tajkhorshid E, Rienstra CM, Kotzbauer PT. Dhavale DD, et al. bioRxiv [Preprint]. 2023 Jan 10:2023.01.09.523303. doi: 10.1101/2023.01.09.523303. bioRxiv. 2023. PMID: 36711931 Free PMC article. Updated. Preprint.
Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.
Miller RL, Dhavale DD, O'Shea JY, Andruska KM, Liu J, Franklin EE, Buddhala C, Loftin SK, Cirrito JR, Perrin RJ, Cairns NJ, Campbell MC, Perlmutter JS, Kotzbauer PT. Miller RL, et al. Among authors: o shea jy. Ann Clin Transl Neurol. 2022 Feb;9(2):106-121. doi: 10.1002/acn3.51482. Epub 2022 Jan 21. Ann Clin Transl Neurol. 2022. PMID: 35060360 Free PMC article.
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.
Kim HY, Chia WK, Hsieh CJ, Saturnino Guarino D, Graham TJA, Lengyel-Zhand Z, Schneider M, Tomita C, Lougee MG, Kim HJ, Pagar VV, Lee H, Hou C, Garcia BA, Petersson EJ, O'Shea J, Kotzbauer PT, Mathis CA, Lee VM, Luk KC, Mach RH. Kim HY, et al. J Med Chem. 2023 Sep 14;66(17):12185-12202. doi: 10.1021/acs.jmedchem.3c00779. Epub 2023 Aug 31. J Med Chem. 2023. PMID: 37651366