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Clinical pharmacokinetics of leriglitazone and a translational approach using PBPK modeling to guide the selection of the starting dose in children.
Traver E, Rodríguez-Pascau L, Meya U, Pina G, Pascual S, Poli S, Eckland D, van de Wetering J, Ke A, Lindauer A, Martinell M, Pizcueta P. Traver E, et al. Among authors: pizcueta p. CPT Pharmacometrics Syst Pharmacol. 2024 Mar 29. doi: 10.1002/psp4.13132. Online ahead of print. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38549500 Free article.
The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy.
Rodríguez-Pascau L, Vilalta A, Cerrada M, Traver E, Forss-Petter S, Weinhofer I, Bauer J, Kemp S, Pina G, Pascual S, Meya U, Musolino PL, Berger J, Martinell M, Pizcueta P. Rodríguez-Pascau L, et al. Among authors: pizcueta p. Sci Transl Med. 2021 Jun 2;13(596):eabc0555. doi: 10.1126/scitranslmed.abc0555. Sci Transl Med. 2021. PMID: 34078742
PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia.
Rodríguez-Pascau L, Britti E, Calap-Quintana P, Dong YN, Vergara C, Delaspre F, Medina-Carbonero M, Tamarit J, Pallardó FV, Gonzalez-Cabo P, Ros J, Lynch DR, Martinell M, Pizcueta P. Rodríguez-Pascau L, et al. Among authors: pizcueta p. Neurobiol Dis. 2021 Jan;148:105162. doi: 10.1016/j.nbd.2020.105162. Epub 2020 Nov 7. Neurobiol Dis. 2021. PMID: 33171227 Free article.
Characterization of platelet and soluble-porcine P-selectin (CD62P).
Massaguer A, Engel P, Tovar V, March S, Rigol M, Solanes N, Bosch J, Pizcueta P. Massaguer A, et al. Among authors: pizcueta p. Vet Immunol Immunopathol. 2003 Dec 15;96(3-4):169-81. doi: 10.1016/s0165-2427(03)00163-6. Vet Immunol Immunopathol. 2003. PMID: 14592730
Platelet activation In mice and human Helicobacter pylori infection.
Elizalde JI, Gómez J, Panés J, Lozano M, Casadevall M, Ramírez J, Pizcueta P, Marco F, Rojas FD, Granger DN, Piqué JM. Elizalde JI, et al. Among authors: pizcueta p. J Clin Invest. 1997 Sep 1;100(5):996-1005. doi: 10.1172/JCI119650. J Clin Invest. 1997. PMID: 9276716 Free PMC article.
51 results