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Photocobilins integrate B12 and bilin photochemistry for enzyme control.
Zhang S, Jeffreys LN, Poddar H, Yu Y, Liu C, Patel K, Johannissen LO, Zhu L, Cliff MJ, Yan C, Schirò G, Weik M, Sakuma M, Levy CW, Leys D, Heyes DJ, Scrutton NS. Zhang S, et al. Among authors: leys d. Nat Commun. 2024 Mar 28;15(1):2740. doi: 10.1038/s41467-024-46995-1. Nat Commun. 2024. PMID: 38548733 Free PMC article.
Redox driven B12-ligand switch drives CarH photoresponse.
Poddar H, Rios-Santacruz R, Heyes DJ, Shanmugam M, Brookfield A, Johannissen LO, Levy CW, Jeffreys LN, Zhang S, Sakuma M, Colletier JP, Hay S, Schirò G, Weik M, Scrutton NS, Leys D. Poddar H, et al. Among authors: leys d. Nat Commun. 2023 Aug 21;14(1):5082. doi: 10.1038/s41467-023-40817-6. Nat Commun. 2023. PMID: 37604813 Free PMC article.
Structural basis of kynurenine 3-monooxygenase inhibition.
Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS. Amaral M, et al. Among authors: leys d. Nature. 2013 Apr 18;496(7445):382-5. doi: 10.1038/nature12039. Epub 2013 Apr 10. Nature. 2013. PMID: 23575632 Free PMC article.
Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis.
Zhang S, Heyes DJ, Feng L, Sun W, Johannissen LO, Liu H, Levy CW, Li X, Yang J, Yu X, Lin M, Hardman SJO, Hoeven R, Sakuma M, Hay S, Leys D, Rao Z, Zhou A, Cheng Q, Scrutton NS. Zhang S, et al. Among authors: leys d. Nature. 2019 Oct;574(7780):722-725. doi: 10.1038/s41586-019-1685-2. Epub 2019 Oct 23. Nature. 2019. PMID: 31645759
Flavin doesn't put all oxygens in one basket.
Leys D, Scrutton NS. Leys D, et al. Nat Chem Biol. 2020 May;16(5):485-486. doi: 10.1038/s41589-020-0523-z. Nat Chem Biol. 2020. PMID: 32322093 No abstract available.
A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.
Zhang S, Sakuma M, Deora GS, Levy CW, Klausing A, Breda C, Read KD, Edlin CD, Ross BP, Wright Muelas M, Day PJ, O'Hagan S, Kell DB, Schwarcz R, Leys D, Heyes DJ, Giorgini F, Scrutton NS. Zhang S, et al. Among authors: leys d. Commun Biol. 2019 Jul 24;2:271. doi: 10.1038/s42003-019-0520-5. eCollection 2019. Commun Biol. 2019. PMID: 31372510 Free PMC article.
826 results