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Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia.
Featherstone RE, Li H, Sengar A, Borgmann-Winter KE, Melnychenko O, Crown LM, Gifford RL, Amirfathi F, Banerjee A, Parekh K, Heller M, Zhang W, Marc AD, Salter MW, Siegel SJ, Hahn CG. Featherstone RE, et al. Among authors: melnychenko o. bioRxiv [Preprint]. 2024 Mar 8:2024.03.08.584132. doi: 10.1101/2024.03.08.584132. bioRxiv. 2024. PMID: 38496466 Free PMC article. Preprint.
Calcium/calmodulin-dependent protein kinase IIα heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment.
Featherstone RE, Shimada T, Crown LM, Melnychenko O, Yi J, Matsumoto M, Tajinda K, Mihara T, Adachi M, Siegel SJ. Featherstone RE, et al. Among authors: melnychenko o. Neuroscience. 2022 Sep 1;499:104-117. doi: 10.1016/j.neuroscience.2022.07.023. Epub 2022 Jul 25. Neuroscience. 2022. PMID: 35901933
Src deficient mice demonstrate behavioral and electrophysiological alterations relevant to psychiatric and developmental disease.
Ward KR, Featherstone RE, Naschek MJ, Melnychenko O, Banerjee A, Yi J, Gifford RL, Borgmann-Winter KE, Salter MW, Hahn CG, Siegel SJ. Ward KR, et al. Among authors: melnychenko o. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:84-92. doi: 10.1016/j.pnpbp.2019.02.017. Epub 2019 Feb 28. Prog Neuropsychopharmacol Biol Psychiatry. 2019. PMID: 30826459
Mismatch negativity in preclinical models of schizophrenia.
Featherstone RE, Melnychenko O, Siegel SJ. Featherstone RE, et al. Among authors: melnychenko o. Schizophr Res. 2018 Jan;191:35-42. doi: 10.1016/j.schres.2017.07.039. Epub 2017 Jul 30. Schizophr Res. 2018. PMID: 28768598 Review.
GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome.
Sinclair D, Featherstone R, Naschek M, Nam J, Du A, Wright S, Pance K, Melnychenko O, Weger R, Akuzawa S, Matsumoto M, Siegel SJ. Sinclair D, et al. Among authors: melnychenko o. eNeuro. 2017 Mar 1;4(1):ENEURO.0380-16.2017. doi: 10.1523/ENEURO.0380-16.2017. eCollection 2017 Jan-Feb. eNeuro. 2017. PMID: 28451631 Free PMC article.