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An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes.
Phillips B, Veljkovic E, Boué S, Schlage WK, Vuillaume G, Martin F, Titz B, Leroy P, Buettner A, Elamin A, Oviedo A, Cabanski M, De León H, Guedj E, Schneider T, Talikka M, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J. Phillips B, et al. Among authors: schlage wk. Toxicol Sci. 2016 Feb;149(2):411-32. doi: 10.1093/toxsci/kfv243. Epub 2015 Nov 25. Toxicol Sci. 2016. PMID: 26609137 Free PMC article.
Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.
Zanetti F, Sewer A, Mathis C, Iskandar AR, Kostadinova R, Schlage WK, Leroy P, Majeed S, Guedj E, Trivedi K, Martin F, Elamin A, Merg C, Ivanov NV, Frentzel S, Peitsch MC, Hoeng J. Zanetti F, et al. Among authors: schlage wk. Chem Res Toxicol. 2016 Aug 15;29(8):1252-69. doi: 10.1021/acs.chemrestox.6b00174. Epub 2016 Aug 5. Chem Res Toxicol. 2016. PMID: 27404394
Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke.
Kogel U, Titz B, Schlage WK, Nury C, Martin F, Oviedo A, Lebrun S, Elamin A, Guedj E, Trivedi K, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J. Kogel U, et al. Among authors: schlage wk. Regul Toxicol Pharmacol. 2016 Nov 30;81 Suppl 2:S123-S138. doi: 10.1016/j.yrtph.2016.11.001. Epub 2016 Nov 4. Regul Toxicol Pharmacol. 2016. PMID: 27818347 Free article.
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology.
Phillips BW, Schlage WK, Titz B, Kogel U, Sciuscio D, Martin F, Leroy P, Vuillaume G, Krishnan S, Lee T, Veljkovic E, Elamin A, Merg C, Ivanov NV, Peitsch MC, Hoeng J, Vanscheeuwijck P. Phillips BW, et al. Among authors: schlage wk. Food Chem Toxicol. 2018 Jun;116(Pt B):388-413. doi: 10.1016/j.fct.2018.04.015. Epub 2018 Apr 11. Food Chem Toxicol. 2018. PMID: 29654848 Free article.
Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures.
Zanetti F, Sewer A, Titz B, Schlage WK, Iskandar AR, Kondylis A, Leroy P, Guedj E, Trivedi K, Elamin A, Martin F, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J. Zanetti F, et al. Among authors: schlage wk. Food Chem Toxicol. 2019 Mar;125:252-270. doi: 10.1016/j.fct.2018.12.056. Epub 2019 Jan 2. Food Chem Toxicol. 2019. PMID: 30610935 Free article.
Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case.
Schlage WK, Titz B, Iskandar A, Poussin C, Van der Toorn M, Wong ET, Pratte P, Maeder S, Schaller JP, Pospisil P, Boue S, Vuillaume G, Leroy P, Martin F, Ivanov NV, Peitsch MC, Hoeng J. Schlage WK, et al. Toxicol Rep. 2020 Sep 12;7:1187-1206. doi: 10.1016/j.toxrep.2020.09.004. eCollection 2020. Toxicol Rep. 2020. PMID: 32995294 Free PMC article.
70 results