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Page 1
Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Smith N, Dasgupta M, Wych DC, Dolamore C, Sierra RG, Lisova S, Marchany-Rivera D, Cohen AE, Boutet S, Hunter MS, Kupitz C, Poitevin F, Moss FR 3rd, Mittan-Moreau DW, Brewster AS, Sauter NK, Young ID, Wolff AM, Tiwari VK, Kumar N, Berkowitz DB, Hadt RG, Thompson MC, Follmer AH, Wall ME, Wilson MA. Smith N, et al. Among authors: young id. Sci Adv. 2024 Mar 29;10(13):eadk7201. doi: 10.1126/sciadv.adk7201. Epub 2024 Mar 27. Sci Adv. 2024. PMID: 38536910 Free PMC article.
Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography.
Smith N, Dasgupta M, Wych DC, Dolamore C, Sierra RG, Lisova S, Marchany-Rivera D, Cohen AE, Boutet S, Hunter MS, Kupitz C, Poitevin F, Moss FR 3rd, Brewster AS, Sauter NK, Young ID, Wolff AM, Tiwari VK, Kumar N, Berkowitz DB, Hadt RG, Thompson MC, Follmer AH, Wall ME, Wilson MA. Smith N, et al. Among authors: young id. bioRxiv [Preprint]. 2023 Aug 16:2023.08.15.553460. doi: 10.1101/2023.08.15.553460. bioRxiv. 2023. PMID: 37645800 Free PMC article. Updated. Preprint.
Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography.
Wolff AM, Nango E, Young ID, Brewster AS, Kubo M, Nomura T, Sugahara M, Owada S, Barad BA, Ito K, Bhowmick A, Carbajo S, Hino T, Holton JM, Im D, O'Riordan LJ, Tanaka T, Tanaka R, Sierra RG, Yumoto F, Tono K, Iwata S, Sauter NK, Fraser JS, Thompson MC. Wolff AM, et al. Among authors: young id. Nat Chem. 2023 Nov;15(11):1549-1558. doi: 10.1038/s41557-023-01329-4. Epub 2023 Sep 18. Nat Chem. 2023. PMID: 37723259 Free PMC article.
X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis.
Rabe P, Kamps JJAG, Sutherlin KD, Linyard JDS, Aller P, Pham CC, Makita H, Clifton I, McDonough MA, Leissing TM, Shutin D, Lang PA, Butryn A, Brem J, Gul S, Fuller FD, Kim IS, Cheah MH, Fransson T, Bhowmick A, Young ID, O'Riordan L, Brewster AS, Pettinati I, Doyle M, Joti Y, Owada S, Tono K, Batyuk A, Hunter MS, Alonso-Mori R, Bergmann U, Owen RL, Sauter NK, Claridge TDW, Robinson CV, Yachandra VK, Yano J, Kern JF, Orville AM, Schofield CJ. Rabe P, et al. Among authors: young id. Sci Adv. 2021 Aug 20;7(34):eabh0250. doi: 10.1126/sciadv.abh0250. Print 2021 Aug. Sci Adv. 2021. PMID: 34417180 Free PMC article.
Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade.
Tetreau G, Banneville AS, Andreeva EA, Brewster AS, Hunter MS, Sierra RG, Teulon JM, Young ID, Burke N, Grünewald TA, Beaudouin J, Snigireva I, Fernandez-Luna MT, Burt A, Park HW, Signor L, Bafna JA, Sadir R, Fenel D, Boeri-Erba E, Bacia M, Zala N, Laporte F, Després L, Weik M, Boutet S, Rosenthal M, Coquelle N, Burghammer M, Cascio D, Sawaya MR, Winterhalter M, Gratton E, Gutsche I, Federici B, Pellequer JL, Sauter NK, Colletier JP. Tetreau G, et al. Among authors: young id. Nat Commun. 2020 Mar 2;11(1):1153. doi: 10.1038/s41467-020-14894-w. Nat Commun. 2020. PMID: 32123169 Free PMC article.
Room temperature XFEL crystallography reveals asymmetry in the vicinity of the two phylloquinones in photosystem I.
Keable SM, Kölsch A, Simon PS, Dasgupta M, Chatterjee R, Subramanian SK, Hussein R, Ibrahim M, Kim IS, Bogacz I, Makita H, Pham CC, Fuller FD, Gul S, Paley D, Lassalle L, Sutherlin KD, Bhowmick A, Moriarty NW, Young ID, Blaschke JP, de Lichtenberg C, Chernev P, Cheah MH, Park S, Park G, Kim J, Lee SJ, Park J, Tono K, Owada S, Hunter MS, Batyuk A, Oggenfuss R, Sander M, Zerdane S, Ozerov D, Nass K, Lemke H, Mankowsky R, Brewster AS, Messinger J, Sauter NK, Yachandra VK, Yano J, Zouni A, Kern J. Keable SM, et al. Among authors: young id. Sci Rep. 2021 Nov 8;11(1):21787. doi: 10.1038/s41598-021-00236-3. Sci Rep. 2021. PMID: 34750381 Free PMC article.
Interpreting macromolecular diffraction through simulation.
Young ID, Mendez D, Poon BK, Blaschke JP, Wittwer F, Wall ME, Sauter NK. Young ID, et al. Methods Enzymol. 2023;688:195-222. doi: 10.1016/bs.mie.2023.06.011. Epub 2023 Aug 10. Methods Enzymol. 2023. PMID: 37748827
Concentric-flow electrokinetic injector enables serial crystallography of ribosome and photosystem II.
Sierra RG, Gati C, Laksmono H, Dao EH, Gul S, Fuller F, Kern J, Chatterjee R, Ibrahim M, Brewster AS, Young ID, Michels-Clark T, Aquila A, Liang M, Hunter MS, Koglin JE, Boutet S, Junco EA, Hayes B, Bogan MJ, Hampton CY, Puglisi EV, Sauter NK, Stan CA, Zouni A, Yano J, Yachandra VK, Soltis SM, Puglisi JD, DeMirci H. Sierra RG, et al. Among authors: young id. Nat Methods. 2016 Jan;13(1):59-62. doi: 10.1038/nmeth.3667. Epub 2015 Nov 30. Nat Methods. 2016. PMID: 26619013 Free PMC article.
Photoreversible interconversion of a phytochrome photosensory module in the crystalline state.
Burgie ES, Clinger JA, Miller MD, Brewster AS, Aller P, Butryn A, Fuller FD, Gul S, Young ID, Pham CC, Kim IS, Bhowmick A, O'Riordan LJ, Sutherlin KD, Heinemann JV, Batyuk A, Alonso-Mori R, Hunter MS, Koglin JE, Yano J, Yachandra VK, Sauter NK, Cohen AE, Kern J, Orville AM, Phillips GN Jr, Vierstra RD. Burgie ES, et al. Among authors: young id. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):300-307. doi: 10.1073/pnas.1912041116. Epub 2019 Dec 18. Proc Natl Acad Sci U S A. 2020. PMID: 31852825 Free PMC article.
Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.
Wolff AM, Young ID, Sierra RG, Brewster AS, Martynowycz MW, Nango E, Sugahara M, Nakane T, Ito K, Aquila A, Bhowmick A, Biel JT, Carbajo S, Cohen AE, Cortez S, Gonzalez A, Hino T, Im D, Koralek JD, Kubo M, Lazarou TS, Nomura T, Owada S, Samelson AJ, Tanaka T, Tanaka R, Thompson EM, van den Bedem H, Woldeyes RA, Yumoto F, Zhao W, Tono K, Boutet S, Iwata S, Gonen T, Sauter NK, Fraser JS, Thompson MC. Wolff AM, et al. Among authors: young id. IUCrJ. 2020 Feb 26;7(Pt 2):306-323. doi: 10.1107/S205225252000072X. eCollection 2020 Mar 1. IUCrJ. 2020. PMID: 32148858 Free PMC article.
214 results