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Population pharmacokinetic analysis of ulotaront in subjects with schizophrenia.
Galluppi GR, Polhamus DG, Fisher JM, Hopkins SC, Koblan KS. Galluppi GR, et al. Among authors: hopkins sc. CPT Pharmacometrics Syst Pharmacol. 2021 Oct;10(10):1245-1254. doi: 10.1002/psp4.12692. Epub 2021 Aug 10. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34292664 Free PMC article.
ECG Evaluation as Part of the Clinical Pharmacology Strategy in the Development of New Drugs: A Review of Current Practices and Opportunities Based on Five Case Studies.
Darpo B, Borin M, Ferber G, Galluppi GR, Hopkins SC, Landry I, Lo A, Rege B, Reyderman L, Sun L, Watanabe T, Xue H, Yasuda S. Darpo B, et al. Among authors: hopkins sc. J Clin Pharmacol. 2022 Dec;62(12):1480-1500. doi: 10.1002/jcph.2095. Epub 2022 Jul 1. J Clin Pharmacol. 2022. PMID: 35665514 Free PMC article. Review.
A Phase I, Open-Label, Fixed Sequence Study to Investigate the Effect of Cytochrome P450 2D6 Inhibition on the Pharmacokinetics of Ulotaront in Healthy Subjects.
Tsukada H, Chen YL, Xiao G, Lennek L, Milanovic SM, Worden M, Polhamus DG, Chiu YY, Hopkins SC, Galluppi GR. Tsukada H, et al. Among authors: hopkins sc. Clin Pharmacokinet. 2023 Dec;62(12):1755-1763. doi: 10.1007/s40262-023-01317-4. Epub 2023 Oct 26. Clin Pharmacokinet. 2023. PMID: 37882999 Free PMC article.
The rate of dasotraline brain entry is slow following intravenous administration.
Lew R, Constantinescu CC, Holden D, Carson RE, Carroll V, Galluppi G, Koblan KS, Hopkins SC. Lew R, et al. Among authors: hopkins sc. Psychopharmacology (Berl). 2020 Nov;237(11):3435-3446. doi: 10.1007/s00213-020-05623-8. Epub 2020 Aug 19. Psychopharmacology (Berl). 2020. PMID: 32813030 Free PMC article.
Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia.
Heffernan MLR, Herman LW, Brown S, Jones PG, Shao L, Hewitt MC, Campbell JE, Dedic N, Hopkins SC, Koblan KS, Xie L. Heffernan MLR, et al. Among authors: hopkins sc. ACS Med Chem Lett. 2021 Dec 6;13(1):92-98. doi: 10.1021/acsmedchemlett.1c00527. eCollection 2022 Jan 13. ACS Med Chem Lett. 2021. PMID: 35047111 Free PMC article.
85 results