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Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo.
Randolph JT, O'Connor MJ, Han F, Hutchins CW, Siu YA, Cho M, Zheng Y, Hickson JA, Markley JL, Manaves V, Algire M, Baker KA, Chapman AM, Gopalakrishnan SM, Panchal SC, Foster-Duke K, Stolarik DF, Kempf-Grote A, Dammeier D, Fossey S, Sun Q, Sun C, Shen Y, Dart MJ, Kati WM, Lai A, Firestone AJ, Kort ME. Randolph JT, et al. Among authors: dart mj. J Med Chem. 2023 Mar 23;66(6):3852-3865. doi: 10.1021/acs.jmedchem.2c01415. Epub 2023 Mar 6. J Med Chem. 2023. PMID: 36877935
Simple, Rapid Chemical Labeling and Screening of Antibodies with Luminescent Peptides.
Kincaid VA, Wang H, Sondgeroth CA, Torio EA, Ressler VT, Fitzgerald C, Hall MP, Hurst R, Wood MG, Gilden JK, Kirkland TA, Lazar D, Chia-Chang H, Encell LP, Machleidt T, Zhou W, Dart ML. Kincaid VA, et al. Among authors: dart ml. ACS Chem Biol. 2022 Aug 19;17(8):2179-2187. doi: 10.1021/acschembio.2c00306. Epub 2022 Jul 21. ACS Chem Biol. 2022. PMID: 35862857 Free PMC article.
eIF2B activator prevents neurological defects caused by a chronic integrated stress response.
Wong YL, LeBon L, Basso AM, Kohlhaas KL, Nikkel AL, Robb HM, Donnelly-Roberts DL, Prakash J, Swensen AM, Rubinstein ND, Krishnan S, McAllister FE, Haste NV, O'Brien JJ, Roy M, Ireland A, Frost JM, Shi L, Riedmaier S, Martin K, Dart MJ, Sidrauski C. Wong YL, et al. Among authors: dart mj. Elife. 2019 Jan 9;8:e42940. doi: 10.7554/eLife.42940. Elife. 2019. PMID: 30624206 Free PMC article.
Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift.
Dart ML, Machleidt T, Jost E, Schwinn MK, Robers MB, Shi C, Kirkland TA, Killoran MP, Wilkinson JM, Hartnett JR, Zimmerman K, Wood KV. Dart ML, et al. ACS Med Chem Lett. 2018 Apr 16;9(6):546-551. doi: 10.1021/acsmedchemlett.8b00081. eCollection 2018 Jun 14. ACS Med Chem Lett. 2018. PMID: 29937980 Free PMC article.
Leukocyte-Associated Ig-like Receptor 1 Inhibits Th1 Responses but Is Required for Natural and Induced Monocyte-Dependent Th17 Responses.
Agashe VV, Jankowska-Gan E, Keller M, Sullivan JA, Haynes LD, Kernien JF, Torrealba JR, Roenneburg D, Dart M, Colonna M, Wilkes DS, Burlingham WJ. Agashe VV, et al. Among authors: dart m. J Immunol. 2018 Jul 15;201(2):772-781. doi: 10.4049/jimmunol.1701753. Epub 2018 Jun 8. J Immunol. 2018. PMID: 29884698 Free PMC article.
44 results