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Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach.
Mahoney SA, VanDongen NS, Greenberg NT, Venkatasubramanian R, Rossman MJ, Widlansky ME, Brunt VE, Bernaldo de Quirós Y, Seals DR, Clayton ZS. Mahoney SA, et al. Among authors: greenberg nt. Am J Physiol Heart Circ Physiol. 2024 May 1;326(5):H1279-H1290. doi: 10.1152/ajpheart.00014.2024. Epub 2024 Mar 22. Am J Physiol Heart Circ Physiol. 2024. PMID: 38517225 Free article.
Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging.
Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. Clayton ZS, et al. Among authors: greenberg nt. Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H185-H196. doi: 10.1152/ajpheart.00118.2021. Epub 2021 Jun 11. Am J Physiol Heart Circ Physiol. 2021. PMID: 34114892 Free PMC article.
Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice.
Brunt VE, Greenberg NT, Sapinsley ZJ, Casso AG, Richey JJ, VanDongen NS, Gioscia-Ryan RA, Ziemba BP, Neilson AP, Davy KP, Seals DR. Brunt VE, et al. Among authors: greenberg nt. J Appl Physiol (1985). 2022 Oct 1;133(4):798-813. doi: 10.1152/japplphysiol.00350.2022. Epub 2022 Aug 11. J Appl Physiol (1985). 2022. PMID: 35952350 Free PMC article.
Female C57BL/6N mice are a viable model of aortic aging in women.
Longtine AG, Venkatasubramanian R, Zigler MC, Lindquist AJ, Mahoney SA, Greenberg NT, VanDongen NS, Ludwig KR, Moreau KL, Seals DR, Clayton ZS. Longtine AG, et al. Among authors: greenberg nt. Am J Physiol Heart Circ Physiol. 2023 Jun 1;324(6):H893-H904. doi: 10.1152/ajpheart.00120.2023. Epub 2023 Apr 28. Am J Physiol Heart Circ Physiol. 2023. PMID: 37115626
Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment.
Clayton ZS, Rossman MJ, Mahoney SA, Venkatasubramanian R, Maurer GS, Hutton DA, VanDongen NS, Greenberg NT, Longtine AG, Ludwig KR, Brunt VE, LaRocca TJ, Campisi J, Melov S, Seals DR. Clayton ZS, et al. Among authors: greenberg nt. Hypertension. 2023 Oct;80(10):2072-2087. doi: 10.1161/HYPERTENSIONAHA.123.21392. Epub 2023 Aug 18. Hypertension. 2023. PMID: 37593877
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.
Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. Mahoney SA, et al. Among authors: greenberg nt. Aging Cell. 2024 Mar;23(3):e14060. doi: 10.1111/acel.14060. Epub 2023 Dec 7. Aging Cell. 2024. PMID: 38062873 Free PMC article.