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Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis.
Kekessie I, Wegner K, Martinez I, Kopach ME, White TD, Tom JK, Kenworthy MN, Gallou F, Lopez J, Koenig SG, Payne PR, Eissler S, Arumugam B, Li C, Mukherjee S, Isidro-Llobet A, Ludemann-Hombourger O, Richardson P, Kittelmann J, Sejer Pedersen D, van den Bos LJ. Kekessie I, et al. Among authors: richardson p. J Org Chem. 2024 Apr 5;89(7):4261-4282. doi: 10.1021/acs.joc.3c01494. Epub 2024 Mar 20. J Org Chem. 2024. PMID: 38508870 Free PMC article. Review.
Sustainable practices in medicinal chemistry: current state and future directions.
Bryan MC, Dillon B, Hamann LG, Hughes GJ, Kopach ME, Peterson EA, Pourashraf M, Raheem I, Richardson P, Richter D, Sneddon HF. Bryan MC, et al. Among authors: richardson p. J Med Chem. 2013 Aug 8;56(15):6007-21. doi: 10.1021/jm400250p. Epub 2013 May 9. J Med Chem. 2013. PMID: 23586692 Review.
Discovery of N-X anomeric amides as electrophilic halogenation reagents.
Wang Y, Bi C, Kawamata Y, Grant LN, Samp L, Richardson PF, Zhang S, Harper KC, Palkowitz MD, Vasilopoulos A, Collins MR, Oderinde MS, Tyrol CC, Chen D, LaChapelle EA, Bailey JB, Qiao JX, Baran PS. Wang Y, et al. Among authors: richardson pf. Nat Chem. 2024 May 20. doi: 10.1038/s41557-024-01539-4. Online ahead of print. Nat Chem. 2024. PMID: 38769366
Discovery of pyrroloaminopyrazoles as novel PAK inhibitors.
Guo C, McAlpine I, Zhang J, Knighton DD, Kephart S, Johnson MC, Li H, Bouzida D, Yang A, Dong L, Marakovits J, Tikhe J, Richardson P, Guo LC, Kania R, Edwards MP, Kraynov E, Christensen J, Piraino J, Lee J, Dagostino E, Del-Carmen C, Deng YL, Smeal T, Murray BW. Guo C, et al. Among authors: richardson p. J Med Chem. 2012 May 24;55(10):4728-39. doi: 10.1021/jm300204j. Epub 2012 May 14. J Med Chem. 2012. PMID: 22554206
Sustainable Practices in Medicinal Chemistry Part 2: Green by Design.
Aliagas I, Berger R, Goldberg K, Nishimura RT, Reilly J, Richardson P, Richter D, Sherer EC, Sparling BA, Bryan MC. Aliagas I, et al. Among authors: richardson p. J Med Chem. 2017 Jul 27;60(14):5955-5968. doi: 10.1021/acs.jmedchem.6b01837. Epub 2017 Apr 12. J Med Chem. 2017. PMID: 28375009 Review.
Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Johnson TW, Tanis SP, Butler SL, Dalvie D, Delisle DM, Dress KR, Flahive EJ, Hu Q, Kuehler JE, Kuki A, Liu W, McClellan GA, Peng Q, Plewe MB, Richardson PF, Smith GL, Solowiej J, Tran KT, Wang H, Yu X, Zhang J, Zhu H. Johnson TW, et al. Among authors: richardson pf. J Med Chem. 2011 May 12;54(9):3393-417. doi: 10.1021/jm200208d. Epub 2011 Apr 13. J Med Chem. 2011. PMID: 21446745
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
Huang Q, Johnson TW, Bailey S, Brooun A, Bunker KD, Burke BJ, Collins MR, Cook AS, Cui JJ, Dack KN, Deal JG, Deng YL, Dinh D, Engstrom LD, He M, Hoffman J, Hoffman RL, Johnson PS, Kania RS, Lam H, Lam JL, Le PT, Li Q, Lingardo L, Liu W, Lu MW, McTigue M, Palmer CL, Richardson PF, Sach NW, Shen H, Smeal T, Smith GL, Stewart AE, Timofeevski S, Tsaparikos K, Wang H, Zhu H, Zhu J, Zou HY, Edwards MP. Huang Q, et al. Among authors: richardson pf. J Med Chem. 2014 Feb 27;57(4):1170-87. doi: 10.1021/jm401805h. Epub 2014 Feb 6. J Med Chem. 2014. PMID: 24432909 Free article.
2,364 results