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Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis.
Kekessie I, Wegner K, Martinez I, Kopach ME, White TD, Tom JK, Kenworthy MN, Gallou F, Lopez J, Koenig SG, Payne PR, Eissler S, Arumugam B, Li C, Mukherjee S, Isidro-Llobet A, Ludemann-Hombourger O, Richardson P, Kittelmann J, Sejer Pedersen D, van den Bos LJ. Kekessie I, et al. Among authors: isidro llobet a. J Org Chem. 2024 Apr 5;89(7):4261-4282. doi: 10.1021/acs.joc.3c01494. Epub 2024 Mar 20. J Org Chem. 2024. PMID: 38508870 Free PMC article. Review.
A dual-enzyme cleavable linker for antibody-drug conjugates.
Bargh JD , Walsh SJ , Ashman N , Isidro-Llobet A , Carroll JS , Spring DR . Bargh JD , et al. Among authors: isidro llobet a. Chem Commun (Camb). 2021 Apr 11;57(28):3457-3460. doi: 10.1039/d1cc00957e. Epub 2021 Mar 9. Chem Commun (Camb). 2021. PMID: 33687404
In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders.
Vantourout JC, Mason AM, Yuen J, Simpson GL, Evindar G, Kuai L, Hobbs M, Edgar E, Needle S, Bai X, Wilson S, Scott-Stevens P, Traylen W, Lambert K, Young N, Bunally S, Summerfield SG, Snell R, Lad R, Shi E, Skinner S, Shewchuk L, Watson AJB, Chung CW, Pal S, Holt DA, Kallander LS, Prendergast J, Rivera K, Washburn DG, Harpel MR, Arico-Muendel C, Isidro-Llobet A. Vantourout JC, et al. Among authors: isidro llobet a. Bioconjug Chem. 2021 Feb 17;32(2):279-289. doi: 10.1021/acs.bioconjchem.0c00662. Epub 2021 Feb 1. Bioconjug Chem. 2021. PMID: 33523652
Site-selective modification strategies in antibody-drug conjugates.
Walsh SJ , Bargh JD , Dannheim FM , Hanby AR , Seki H , Counsell AJ , Ou X , Fowler E , Ashman N , Takada Y , Isidro-Llobet A , Parker JS , Carroll JS , Spring DR . Walsh SJ , et al. Among authors: isidro llobet a. Chem Soc Rev. 2021 Jan 21;50(2):1305-1353. doi: 10.1039/d0cs00310g. Epub 2020 Dec 8. Chem Soc Rev. 2021. PMID: 33290462 Review.
Sulfatase-cleavable linkers for antibody-drug conjugates.
Bargh JD, Walsh SJ, Isidro-Llobet A, Omarjee S, Carroll JS, Spring DR. Bargh JD, et al. Among authors: isidro llobet a. Chem Sci. 2020 Jan 27;11(9):2375-2380. doi: 10.1039/c9sc06410a. Chem Sci. 2020. PMID: 34084399 Free PMC article.
MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo-allergic and anaphylactoid reactions.
Grimes J, Desai S, Charter NW, Lodge J, Moita Santos R, Isidro-Llobet A, Mason AM, Wu Z, Wolfe LA 3rd, Anantharaman L, Green A, Bridges AM, Dalmas Wilk DA, Brown AJ. Grimes J, et al. Among authors: isidro llobet a. Pharmacol Res Perspect. 2019 Dec 2;7(6):e00547. doi: 10.1002/prp2.547. eCollection 2019 Dec. Pharmacol Res Perspect. 2019. PMID: 31832205 Free PMC article.
Cleavable linkers in antibody-drug conjugates.
Bargh JD , Isidro-Llobet A , Parker JS , Spring DR . Bargh JD , et al. Among authors: isidro llobet a. Chem Soc Rev. 2019 Aug 12;48(16):4361-4374. doi: 10.1039/c8cs00676h. Chem Soc Rev. 2019. PMID: 31294429 Review.
29 results