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The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis.
Sci Transl Med. 2024 Mar 20;16(739):eadk9109. doi: 10.1126/scitranslmed.adk9109. Epub 2024 Mar 20.
Sci Transl Med. 2024.
PMID: 38507469
Clinical Trial.
Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double-blind placebo-controlled cross-over study.
Ruijs TQ, Koopmans IW, de Kam ML, Tannemaat MR, Groeneveld GJ, Heuberger JAAC.
Ruijs TQ, et al.
Clin Transl Sci. 2022 Dec;15(12):2971-2981. doi: 10.1111/cts.13418. Epub 2022 Oct 25.
Clin Transl Sci. 2022.
PMID: 36281627
Free PMC article.
Clinical Trial.
Item in Clipboard
Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.
Ruijs TQ, Koopmans IW, de Kam ML, van Esdonk MJ, Koltzenburg M, Groeneveld GJ, Heuberger JAAC.
Ruijs TQ, et al.
Clin Pharmacol Ther. 2022 Nov;112(5):1008-1019. doi: 10.1002/cpt.2694. Epub 2022 Jul 19.
Clin Pharmacol Ther. 2022.
PMID: 35762293
Free PMC article.
Clinical Trial.
Item in Clipboard
Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double-blind, placebo-controlled, cross-over study.
Ruijs TQ, Heuberger JAAC, de Goede AA, Ziagkos D, Otto ME, Doll RJ, van Putten MJAM, Groeneveld GJ.
Ruijs TQ, et al.
Br J Clin Pharmacol. 2022 Jun;88(6):2926-2937. doi: 10.1111/bcp.15232. Epub 2022 Feb 3.
Br J Clin Pharmacol. 2022.
PMID: 35028950
Free PMC article.
Clinical Trial.
Item in Clipboard
Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation.
O'Donnell P, Dijkstra FM, Damar U, Quanhong L, de Goede AA, Xu L, Pascual-Leone A, Buhl DL, Zuiker R, Ruijs TQ, Heuberger JAAC, MacMullin P, Lubell M, Asgharnejad M, Murthy V, Rotenberg A, Jacobs GE, Rosen L.
O'Donnell P, et al. Among authors: ruijs tq.
Transl Psychiatry. 2021 May 27;11(1):325. doi: 10.1038/s41398-021-01451-2.
Transl Psychiatry. 2021.
PMID: 34045439
Free PMC article.
Clinical Trial.
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