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The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis.
Sci Transl Med. 2024 Mar 20;16(739):eadk9109. doi: 10.1126/scitranslmed.adk9109. Epub 2024 Mar 20.
Sci Transl Med. 2024.
PMID: 38507469
Clinical Trial.
Depletion of ATP Limits Membrane Excitability of Skeletal Muscle by Increasing Both ClC1-Open Probability and Membrane Conductance.
Leermakers PA, Dybdahl KLT, Husted KS, Riisager A, de Paoli FV, Pinós T, Vissing J, Krag TOB, Pedersen TH.
Leermakers PA, et al. Among authors: dybdahl klt.
Front Neurol. 2020 Jun 19;11:541. doi: 10.3389/fneur.2020.00541. eCollection 2020.
Front Neurol. 2020.
PMID: 32655483
Free PMC article.
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