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Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Legru A, Batista FA, Puszko AK, Bouillon A, Maurel M, Martinez M, Ejjoummany A, Ortega Varga L, Adler P, Méchaly A, Hadjadj M, Sosnowski P, Hopfgartner G, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF. Legru A, et al. Among authors: ortega varga l. Eur J Med Chem. 2024 Apr 5;269:116308. doi: 10.1016/j.ejmech.2024.116308. Epub 2024 Mar 11. Eur J Med Chem. 2024. PMID: 38503166
3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor.
Martinez M, Batista FA, Maurel M, Bouillon A, Ortega Varga L, Wehenkel AM, Le Chevalier-Sontag L, Blondel A, Haouz A, Hernandez JF, Alzari PM, Barale JC. Martinez M, et al. Among authors: ortega varga l. Acta Crystallogr D Struct Biol. 2023 Aug 1;79(Pt 8):721-734. doi: 10.1107/S2059798323004710. Epub 2023 Jul 10. Acta Crystallogr D Struct Biol. 2023. PMID: 37428845
A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.
Chen KY, Krischuns T, Ortega Varga L, Harigua-Souiai E, Paisant S, Zettor A, Chiaravalli J, Courtney D, O'Brien A, Baker SC, Isel C, Agou F, Jacob Y, Blondel A, Naffakh N. Chen KY, et al. Among authors: ortega varga l. bioRxiv [Preprint]. 2021 Dec 21:2021.12.18.473303. doi: 10.1101/2021.12.18.473303. bioRxiv. 2021. PMID: 34981051 Free PMC article. Updated. Preprint.