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Lowered PON1 activities are strongly associated with depression and bipolar disorder, recurrence of (hypo)mania and depression, increased disability and lowered quality of life.
Moreira EG, Correia DG, Bonifácio KL, Moraes JB, Cavicchioli FL, Nunes CS, Nunes SOV, Vargas HO, Barbosa DS, Maes M. Moreira EG, et al. Among authors: correia dg. World J Biol Psychiatry. 2019 Jun;20(5):368-380. doi: 10.1080/15622975.2017.1322219. Epub 2017 May 30. World J Biol Psychiatry. 2019. PMID: 28441923
Why Should Psychiatrists and Neuroscientists Worry about Paraoxonase 1?
Moreira EG, Boll KM, Correia DG, Soares JF, Rigobello C, Maes M. Moreira EG, et al. Among authors: correia dg. Curr Neuropharmacol. 2019;17(11):1004-1020. doi: 10.2174/1570159X17666181227164947. Curr Neuropharmacol. 2019. PMID: 30592255 Free PMC article. Review.