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Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics.
Turner L, Van Le TN, Cross E, Queriault C, Knight M, Trihemasava K, Davis J, Schaefer P, Nguyen J, Xu J, Goldspiel B, Hall E, Rome K, Scaglione M, Eggert J, Au-Yeung B, Wallace DC, Mesaros C, Baur JA, Bailis W. Turner L, et al. Among authors: davis j. Sci Immunol. 2024 Mar 15;9(93):eadj7238. doi: 10.1126/sciimmunol.adj7238. Epub 2024 Mar 15. Sci Immunol. 2024. PMID: 38489349 Free PMC article.
Rapamycin maintains NAD+/NADH redox homeostasis in muscle cells.
Zhang Z, Xu HN, Li S, Jr AD, Chellappa K, Davis JG, Guan Y, Frederick DW, Chu W, Zhao H, Li LZ, Baur JA. Zhang Z, et al. Aging (Albany NY). 2020 Sep 22;12(18):17786-17799. doi: 10.18632/aging.103954. Epub 2020 Sep 22. Aging (Albany NY). 2020. PMID: 32960787 Free PMC article.
Conditional ablation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes.
Xiong M, Zhu Z, Tian S, Zhu R, Bai S, Fu K, Davis JG, Sun Z, Baur JA, Zheng K, Ye L. Xiong M, et al. FASEB J. 2017 Sep;31(9):3934-3949. doi: 10.1096/fj.201700251R. Epub 2017 May 10. FASEB J. 2017. PMID: 28490482
Together, these results demonstrate that mTORC1 has an essential role in the meiotic progression and silencing of sex chromosomes in the male germline, which may explain the infertility that has been associated with such inhibitors as rapamycin.-Xiong, M., Zhu, Z., Tian, S., Zhu, …
Together, these results demonstrate that mTORC1 has an essential role in the meiotic progression and silencing of sex chromosomes in the mal …
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