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A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings.
Brum WS, Cullen NC, Therriault J, Janelidze S, Rahmouni N, Stevenson J, Servaes S, Benedet AL, Zimmer ER, Stomrud E, Palmqvist S, Zetterberg H, Frisoni GB, Ashton NJ, Blennow K, Mattsson-Carlgren N, Rosa-Neto P, Hansson O. Brum WS, et al. Nat Commun. 2024 Mar 14;15(1):2311. doi: 10.1038/s41467-024-46603-2. Nat Commun. 2024. PMID: 38486040 Free PMC article.
Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer's pathology.
Therriault J, Ashton NJ, Pola I, Triana-Baltzer G, Brum WS, Di Molfetta G, Arslan B, Rahmouni N, Tissot C, Servaes S, Stevenson J, Macedo AC, Pascoal TA, Kolb HC, Jeromin A, Blennow K, Zetterberg H, Rosa-Neto P, Benedet AL. Therriault J, et al. Among authors: brum ws. EBioMedicine. 2024 Apr;102:105046. doi: 10.1016/j.ebiom.2024.105046. Epub 2024 Mar 11. EBioMedicine. 2024. PMID: 38471397 Free PMC article.
Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer's Disease.
Lantero-Rodriguez J, Salvadó G, Snellman A, Montoliu-Gaya L, Brum WS, Benedet AL, Mattsson-Carlgren N, Tideman P, Janelidze S, Palmqvist S, Stomrud E, Ashton NJ, Zetterberg H, Blennow K, Hansson O. Lantero-Rodriguez J, et al. Among authors: brum ws. Mol Neurodegener. 2024 Feb 17;19(1):19. doi: 10.1186/s13024-024-00707-x. Mol Neurodegener. 2024. PMID: 38365825 Free PMC article.
Vascular risk burden is a key player in the early progression of Alzheimer's disease.
Ferrari-Souza JP, Brum WS, Hauschild LA, Da Ros LU, Ferreira PCL, Bellaver B, Leffa DT, Bieger A, Tissot C, Lussier FZ, De Bastiani MA, Povala G, Benedet AL, Therriault J, Wang YT, Ashton NJ, Zetterberg H, Blennow K, Martins SO, Souza DO, Rosa-Neto P, Karikari TK, Pascoal TA, Zimmer ER; Alzheimer’s Disease Neuroimaging Initiative. Ferrari-Souza JP, et al. Among authors: brum ws. Neurobiol Aging. 2024 Apr;136:88-98. doi: 10.1016/j.neurobiolaging.2023.12.008. Epub 2024 Jan 10. Neurobiol Aging. 2024. PMID: 38335912
Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology.
Ashton NJ, Brum WS, Di Molfetta G, Benedet AL, Arslan B, Jonaitis E, Langhough RE, Cody K, Wilson R, Carlsson CM, Vanmechelen E, Montoliu-Gaya L, Lantero-Rodriguez J, Rahmouni N, Tissot C, Stevenson J, Servaes S, Therriault J, Pascoal T, Lleó A, Alcolea D, Fortea J, Rosa-Neto P, Johnson S, Jeromin A, Blennow K, Zetterberg H. Ashton NJ, et al. Among authors: brum ws. JAMA Neurol. 2024 Mar 1;81(3):255-263. doi: 10.1001/jamaneurol.2023.5319. JAMA Neurol. 2024. PMID: 38252443 Free PMC article.
CSF p-tau205: a biomarker of tau pathology in Alzheimer's disease.
Lantero-Rodriguez J, Montoliu-Gaya L, Benedet AL, Vrillon A, Dumurgier J, Cognat E, Brum WS, Rahmouni N, Stevenson J, Servaes S, Therriault J, Becker B, Brinkmalm G, Snellman A, Huber H, Kvartsberg H, Ashton NJ, Zetterberg H, Paquet C, Rosa-Neto P, Blennow K. Lantero-Rodriguez J, et al. Among authors: brum ws. Acta Neuropathol. 2024 Jan 6;147(1):12. doi: 10.1007/s00401-023-02659-w. Acta Neuropathol. 2024. PMID: 38184490 Free PMC article.
Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy individuals.
Brum WS, Ashton NJ, Simrén J, di Molfetta G, Karikari TK, Benedet AL, Zimmer ER, Lantero-Rodriguez J, Montoliu-Gaya L, Jeromin A, Aarsand AK, Bartlett WA, Calle PF, Coşkun A, Díaz-Garzón J, Jonker N, Zetterberg H, Sandberg S, Carobene A, Blennow K. Brum WS, et al. Alzheimers Dement. 2024 Feb;20(2):1284-1297. doi: 10.1002/alz.13518. Epub 2023 Nov 20. Alzheimers Dement. 2024. PMID: 37985230 Free PMC article.
A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases.
Brum WS, Cullen NC, Janelidze S, Ashton NJ, Zimmer ER, Therriault J, Benedet AL, Rahmouni N, Tissot C, Stevenson J, Servaes S, Triana-Baltzer G, Kolb HC, Palmqvist S, Stomrud E, Rosa-Neto P, Blennow K, Hansson O. Brum WS, et al. Nat Aging. 2023 Sep;3(9):1079-1090. doi: 10.1038/s43587-023-00471-5. Epub 2023 Aug 31. Nat Aging. 2023. PMID: 37653254 Free PMC article.
38 results