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Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma.
Ringwalt EM, Currier MA, Glaspell AM, Chen CY, Cannon MV, Cam M, Gross AC, Gust M, Wang PY, Boon L, Biederman LE, Schwarz E, Rajappa P, Lee DA, Mardis ER, Carson WE, Roberts RD, Cripe TP. Ringwalt EM, et al. Among authors: roberts rd. bioRxiv [Preprint]. 2024 Mar 3:2024.03.02.582994. doi: 10.1101/2024.03.02.582994. bioRxiv. 2024. PMID: 38464161 Free PMC article. Preprint.
IL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis.
Gross AC, Cam H, Phelps DA, Saraf AJ, Bid HK, Cam M, London CA, Winget SA, Arnold MA, Brandolini L, Mo X, Hinckley JM, Houghton PJ, Roberts RD. Gross AC, et al. Among authors: roberts rd. JCI Insight. 2018 Aug 23;3(16):e99791. doi: 10.1172/jci.insight.99791. eCollection 2018 Aug 23. JCI Insight. 2018. PMID: 30135299 Free PMC article.
Immunotherapeutic Challenges for Pediatric Cancers.
Hutzen B, Ghonime M, Lee J, Mardis ER, Wang R, Lee DA, Cairo MS, Roberts RD, Cripe TP, Cassady KA. Hutzen B, et al. Among authors: roberts rd. Mol Ther Oncolytics. 2019 Aug 28;15:38-48. doi: 10.1016/j.omto.2019.08.005. eCollection 2019 Dec 20. Mol Ther Oncolytics. 2019. PMID: 31650024 Free PMC article. Review.
Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma.
Wedekind MF, Miller KE, Chen CY, Wang PY, Hutzen BJ, Currier MA, Nartker B, Roberts RD, Boon L, Conner J, LaHaye S, Kelly BJ, Gordon D, White P, Mardis ER, Cripe TP. Wedekind MF, et al. Among authors: roberts rd. iScience. 2021 Jun 19;24(7):102759. doi: 10.1016/j.isci.2021.102759. eCollection 2021 Jul 23. iScience. 2021. PMID: 34278266 Free PMC article.
Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma.
Rajendran S, Hu Y, Canella A, Peterson C, Gross A, Cam M, Nazzaro M, Haffey A, Serin-Harmanci A, Distefano R, Nigita G, Wang W, Kreatsoulas D, Li Z, Sepeda JA, Sas A, Hester ME, Miller KE, Elemento O, Roberts RD, Holland EC, Rao G, Mardis ER, Rajappa P. Rajendran S, et al. Among authors: roberts rd. Cell Rep. 2023 Mar 28;42(3):112197. doi: 10.1016/j.celrep.2023.112197. Epub 2023 Mar 3. Cell Rep. 2023. PMID: 36871221 Free article.
Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution.
Hedberg J, Studebaker A, Smith L, Chen CY, Westfall JJ, Cam M, Gross A, Hernandez-Aguirre I, Martin A, Kim D, Dhital R, Kim Y, Roberts RD, Cripe TP, Mardis ER, Cassady KA, Leonard J, Miller KE. Hedberg J, et al. Among authors: roberts rd. Mol Ther Oncolytics. 2023 Jul 19;30:39-55. doi: 10.1016/j.omto.2023.07.006. eCollection 2023 Sep 21. Mol Ther Oncolytics. 2023. PMID: 37583388 Free PMC article.
Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
McAloney CA, Makkawi R, Budhathoki Y, Cannon MV, Franz EM, Gross AC, Cam M, Vetter TA, Duhen R, Davies AE, Roberts RD. McAloney CA, et al. Among authors: roberts rd. Cell Oncol (Dordr). 2024 Feb;47(1):259-282. doi: 10.1007/s13402-023-00867-w. Epub 2023 Sep 7. Cell Oncol (Dordr). 2024. PMID: 37676378 Free PMC article.
111 results