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172 results

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Page 1
Discovery of a proteinaceous cellular receptor for a norovirus.
Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW. Orchard RC, et al. Among authors: doench jg. Science. 2016 Aug 26;353(6302):933-6. doi: 10.1126/science.aaf1220. Epub 2016 Aug 18. Science. 2016. PMID: 27540007 Free PMC article.
Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock.
Orvedahl A, McAllaster MR, Sansone A, Dunlap BF, Desai C, Wang YT, Balce DR, Luke CJ, Lee S, Orchard RC, Artyomov MN, Handley SA, Doench JG, Silverman GA, Virgin HW. Orvedahl A, et al. Among authors: doench jg. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16497-16506. doi: 10.1073/pnas.1822157116. Epub 2019 Jul 25. Proc Natl Acad Sci U S A. 2019. PMID: 31346084 Free PMC article.
Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection.
Wei J, Alfajaro MM, Hanna RE, DeWeirdt PC, Strine MS, Lu-Culligan WJ, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Gasque V, de Miguel F, Chen H, Oguntuyo K, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach B, Politi K, van Dijk D, Simon MD, Yan Q, Doench JG, Wilen CB. Wei J, et al. Among authors: doench jg. bioRxiv [Preprint]. 2020 Jun 17:2020.06.16.155101. doi: 10.1101/2020.06.16.155101. bioRxiv. 2020. PMID: 32869025 Free PMC article. Updated. Preprint.
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.
Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB. Wei J, et al. Among authors: doench jg. Cell. 2021 Jan 7;184(1):76-91.e13. doi: 10.1016/j.cell.2020.10.028. Epub 2020 Oct 20. Cell. 2021. PMID: 33147444 Free PMC article.
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity.
Brestoff JR, Wilen CB, Moley JR, Li Y, Zou W, Malvin NP, Rowen MN, Saunders BT, Ma H, Mack MR, Hykes BL Jr, Balce DR, Orvedahl A, Williams JW, Rohatgi N, Wang X, McAllaster MR, Handley SA, Kim BS, Doench JG, Zinselmeyer BH, Diamond MS, Virgin HW, Gelman AE, Teitelbaum SL. Brestoff JR, et al. Among authors: doench jg. Cell Metab. 2021 Feb 2;33(2):270-282.e8. doi: 10.1016/j.cmet.2020.11.008. Epub 2020 Dec 4. Cell Metab. 2021. PMID: 33278339 Free PMC article.
UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages.
Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings CL, Virgin HW. Balce DR, et al. Among authors: doench jg. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2011763118. doi: 10.1073/pnas.2011763118. Proc Natl Acad Sci U S A. 2021. PMID: 33372156 Free PMC article.
Selective Polyprotein Processing Determines Norovirus Sensitivity to Trim7.
Sullender ME, Pierce LR, Annaswamy Srinivas M, Crockett SL, Dunlap BF, Rodgers R, Schriefer LA, Kennedy EA, Stewart BM, Doench JG, Baldridge MT, Orchard RC. Sullender ME, et al. Among authors: doench jg. J Virol. 2022 Sep 14;96(17):e0070722. doi: 10.1128/jvi.00707-22. Epub 2022 Aug 16. J Virol. 2022. PMID: 35972292 Free PMC article.
172 results