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Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development.
Kim T, Martínez-Bonet M, Wang Q, Hackert N, Sparks JA, Baglaenko Y, Koh B, Darbousset R, Laza-Briviesca R, Chen X, Aguiar VRC, Chiu DJ, Westra HJ, Gutierrez-Arcelus M, Weirauch MT, Raychaudhuri S, Rao DA, Nigrovic PA. Kim T, et al. Among authors: sparks ja. Nat Commun. 2024 Mar 9;15(1):2150. doi: 10.1038/s41467-024-46457-8. Nat Commun. 2024. PMID: 38459032 Free PMC article.
A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.
Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC. Chang HH, et al. Among authors: sparks ja. JCI Insight. 2016 Oct 20;1(17):e90045. doi: 10.1172/jci.insight.90045. JCI Insight. 2016. PMID: 27777982 Free PMC article.
Investigating methotrexate toxicity within a randomized double-blinded, placebo-controlled trial: Rationale and design of the Cardiovascular Inflammation Reduction Trial-Adverse Events (CIRT-AE) Study.
Sparks JA, Barbhaiya M, Karlson EW, Ritter SY, Raychaudhuri S, Corrigan CC, Lu F, Selhub J, Chasman DI, Paynter NP, Ridker PM, Solomon DH. Sparks JA, et al. Semin Arthritis Rheum. 2017 Aug;47(1):133-142. doi: 10.1016/j.semarthrit.2017.02.003. Epub 2017 Feb 10. Semin Arthritis Rheum. 2017. PMID: 28284844 Free PMC article. Clinical Trial.
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation.
Simmons DP, Nguyen HN, Gomez-Rivas E, Jeong Y, Jonsson AH, Chen AF, Lange JK, Dyer GS, Blazar P, Earp BE, Coblyn JS, Massarotti EM, Sparks JA, Todd DJ; Accelerating Medicines Partnership (AMP) RA/SLE Network; Rao DA, Kim EY, Brenner MB. Simmons DP, et al. Among authors: sparks ja. Sci Immunol. 2022 Feb 11;7(68):eabf2846. doi: 10.1126/sciimmunol.abf2846. Epub 2022 Feb 11. Sci Immunol. 2022. PMID: 35148199 Free PMC article.
Longitudinal Immune Cell Profiling in Patients With Early Systemic Lupus Erythematosus.
Sasaki T, Bracero S, Keegan J, Chen L, Cao Y, Stevens E, Qu Y, Wang G, Nguyen J, Sparks JA, Holers VM, Alves SE, Lederer JA, Costenbader KH, Rao DA. Sasaki T, et al. Among authors: sparks ja. Arthritis Rheumatol. 2022 Nov;74(11):1808-1821. doi: 10.1002/art.42248. Epub 2022 Oct 7. Arthritis Rheumatol. 2022. PMID: 35644031 Free PMC article.
Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis.
Wang R, Singaraju A, Marks KE, Shakib L, Dunlap G, Adejoorin I, Greisen SR, Chen L, Tirpack AK, Aude C, Fein MR, Todd DJ, MacFarlane L, Goodman SM, DiCarlo EF, Massarotti EM, Sparks JA, Jonsson AH, Brenner MB, Postow MA, Chan KK, Bass AR, Donlin LT, Rao DA. Wang R, et al. Among authors: sparks ja. Sci Immunol. 2023 Jul 28;8(85):eadd1591. doi: 10.1126/sciimmunol.add1591. Epub 2023 Jul 28. Sci Immunol. 2023. PMID: 37506196 Free PMC article.
High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.
Nigrovic PA, Wang Q, Kim T, Martinez-Bonet M, Aguiar VRC, Sim S, Cui J, Sparks JA, Chen X, Todd M, Wauford B, Marion MC, Langefeld CD, Weirauch MT, Gutierrez-Arcelus M. Nigrovic PA, et al. Among authors: sparks ja. bioRxiv [Preprint]. 2024 Apr 12:2023.08.16.553538. doi: 10.1101/2023.08.16.553538. bioRxiv. 2024. PMID: 37645953 Free PMC article. Preprint.
Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases.
Herman JD, Atyeo C, Zur Y, Cook CE, Patel NJ, Vanni KM, Kowalski EN, Qian G, Srivatsan S, Shadick NA, Rao DA, Kellman B, Mann CJ, Lauffenburger D, Wallace ZS, Sparks JA, Alter G. Herman JD, et al. Among authors: sparks ja. Sci Transl Med. 2023 Sep 6;15(712):eadf6598. doi: 10.1126/scitranslmed.adf6598. Epub 2023 Sep 6. Sci Transl Med. 2023. PMID: 37672567 Free PMC article.
296 results