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Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols.
Barboy O, Bercovich A, Li H, Eyal-Lubling Y, Yalin A, Shapir Itai Y, Abadie K, Zada M, David E, Shlomi-Loubaton S, Katzenelenbogen Y, Jaitin DA, Gur C, Yofe I, Feferman T, Cohen M, Dahan R, Newell EW, Lifshitz A, Tanay A, Amit I. Barboy O, et al. Among authors: newell ew. Nat Cancer. 2024 May;5(5):742-759. doi: 10.1038/s43018-024-00734-z. Epub 2024 Mar 1. Nat Cancer. 2024. PMID: 38429414
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.
McGovern N, Shin A, Low G, Low D, Duan K, Yao LJ, Msallam R, Low I, Shadan NB, Sumatoh HR, Soon E, Lum J, Mok E, Hubert S, See P, Kunxiang EH, Lee YH, Janela B, Choolani M, Mattar CNZ, Fan Y, Lim TKH, Chan DKH, Tan KK, Tam JKC, Schuster C, Elbe-Bürger A, Wang XN, Bigley V, Collin M, Haniffa M, Schlitzer A, Poidinger M, Albani S, Larbi A, Newell EW, Chan JKY, Ginhoux F. McGovern N, et al. Among authors: newell ew. Nature. 2017 Jun 29;546(7660):662-666. doi: 10.1038/nature22795. Epub 2017 Jun 14. Nature. 2017. PMID: 28614294 Free PMC article.
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans.
Galletti G, De Simone G, Mazza EMC, Puccio S, Mezzanotte C, Bi TM, Davydov AN, Metsger M, Scamardella E, Alvisi G, De Paoli F, Zanon V, Scarpa A, Camisa B, Colombo FS, Anselmo A, Peano C, Polletti S, Mavilio D, Gattinoni L, Boi SK, Youngblood BA, Jones RE, Baird DM, Gostick E, Llewellyn-Lacey S, Ladell K, Price DA, Chudakov DM, Newell EW, Casucci M, Lugli E. Galletti G, et al. Among authors: newell ew. Nat Immunol. 2020 Dec;21(12):1552-1562. doi: 10.1038/s41590-020-0791-5. Epub 2020 Oct 12. Nat Immunol. 2020. PMID: 33046887 Free PMC article.
Intratumoral CD39+CD8+ T Cells Predict Response to Programmed Cell Death Protein-1 or Programmed Death Ligand-1 Blockade in Patients With NSCLC.
Yeong J, Suteja L, Simoni Y, Lau KW, Tan AC, Li HH, Lim S, Loh JH, Wee FYT, Nerurkar SN, Takano A, Tan EH, Lim TKH, Newell EW, Tan DSW. Yeong J, et al. Among authors: newell ew. J Thorac Oncol. 2021 Aug;16(8):1349-1358. doi: 10.1016/j.jtho.2021.04.016. Epub 2021 May 8. J Thorac Oncol. 2021. PMID: 33975004 Free article.
Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function.
Veatch JR, Lee SM, Shasha C, Singhi N, Szeto JL, Moshiri AS, Kim TS, Smythe K, Kong P, Fitzgibbon M, Jesernig B, Bhatia S, Tykodi SS, Hall ET, Byrd DR, Thompson JA, Pillarisetty VG, Duhen T, McGarry Houghton A, Newell E, Gottardo R, Riddell SR. Veatch JR, et al. Cancer Cell. 2022 Apr 11;40(4):393-409.e9. doi: 10.1016/j.ccell.2022.03.006. Cancer Cell. 2022. PMID: 35413271 Free PMC article.
Single-cell analysis reveals clonally expanded tumor-associated CD57+ CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade.
Fehlings M, Kim L, Guan X, Yuen K, Tafazzol A, Sanjabi S, Zill OA, Rishipathak D, Wallace A, Nardin A, Ma S, Milojkovic A, Newell EW, Mariathasan S, Yadav M. Fehlings M, et al. Among authors: newell ew. J Immunother Cancer. 2022 Aug;10(8):e004759. doi: 10.1136/jitc-2022-004759. J Immunother Cancer. 2022. PMID: 35981786 Free PMC article.
154 results