Hanke T - Search Results

1

Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.

Rak M, Menge A, Tesch R, Berger LM, Balourdas DI, Shevchenko E, Krämer A, Elson L, Berger BT, Abdi I, Wahl LM, Poso A, Kaiser A, Hanke T, Kronenberger T, Joerger AC, Müller S, Knapp S. Rak M, et al. Among authors: hanke t. J Med Chem. 2024 Mar 14;67(5):3813-3842. doi: 10.1021/acs.jmedchem.3c02217. Epub 2024 Feb 29. J Med Chem. 2024. PMID: 38422480

2

Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor.

Krämer A, Kurz CG, Berger BT, Celik IE, Tjaden A, Greco FA, Knapp S, Hanke T. Krämer A, et al. Among authors: hanke t. Eur J Med Chem. 2020 Dec 15;208:112770. doi: 10.1016/j.ejmech.2020.112770. Epub 2020 Aug 23. Eur J Med Chem. 2020. PMID: 32883634

3

Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.

Tesch R, Rak M, Raab M, Berger LM, Kronenberger T, Joerger AC, Berger BT, Abdi I, Hanke T, Poso A, Strebhardt K, Sanhaji M, Knapp S. Tesch R, et al. Among authors: hanke t. J Med Chem. 2021 Jun 24;64(12):8142-8160. doi: 10.1021/acs.jmedchem.0c02144. Epub 2021 Jun 4. J Med Chem. 2021. PMID: 34086472

4

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles.

Kurz CG, Preuss F, Tjaden A, Cusack M, Amrhein JA, Chatterjee D, Mathea S, Berger LM, Berger BT, Krämer A, Weller M, Weiss T, Müller S, Knapp S, Hanke T. Kurz CG, et al. Among authors: hanke t. J Med Chem. 2022 Jun 9;65(11):7799-7817. doi: 10.1021/acs.jmedchem.2c00173. Epub 2022 May 24. J Med Chem. 2022. PMID: 35608370

5

Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.

Hanke T, Mathea S, Woortman J, Salah E, Berger BT, Tumber A, Kashima R, Hata A, Kuster B, Müller S, Knapp S. Hanke T, et al. J Med Chem. 2022 Oct 13;65(19):13264-13287. doi: 10.1021/acs.jmedchem.2c01106. Epub 2022 Sep 22. J Med Chem. 2022. PMID: 36136092 Free PMC article.

6

Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2.

Amrhein JA, Wang G, Berger BT, Berger LM, Kalampaliki AD, Krämer A, Knapp S, Hanke T. Amrhein JA, et al. Among authors: hanke t. ACS Med Chem Lett. 2023 May 30;14(6):833-840. doi: 10.1021/acsmedchemlett.3c00127. eCollection 2023 Jun 8. ACS Med Chem Lett. 2023. PMID: 37312836

7

Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.

Amrhein JA, Berger LM, Balourdas DI, Joerger AC, Menge A, Krämer A, Frischkorn JM, Berger BT, Elson L, Kaiser A, Schubert-Zsilavecz M, Müller S, Knapp S, Hanke T. Amrhein JA, et al. Among authors: hanke t. J Med Chem. 2024 Jan 11;67(1):674-690. doi: 10.1021/acs.jmedchem.3c01980. Epub 2023 Dec 21. J Med Chem. 2024. PMID: 38126712

8

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.

Hanke T, Wong JF, Berger BT, Abdi I, Berger LM, Tesch R, Tredup C, Bullock AN, Müller S, Knapp S. Hanke T, et al. ACS Chem Biol. 2020 Apr 17;15(4):862-870. doi: 10.1021/acschembio.0c00076. Epub 2020 Mar 20. ACS Chem Biol. 2020. PMID: 32176847

9

Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors.

Amrhein JA, Knapp S, Hanke T. Amrhein JA, et al. Among authors: hanke t. J Med Chem. 2021 Jun 24;64(12):7991-8009. doi: 10.1021/acs.jmedchem.1c00217. Epub 2021 Jun 2. J Med Chem. 2021. PMID: 34076436 Review.

10

Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.

Amrhein JA, Beyett TS, Feng WW, Krämer A, Weckesser J, Schaeffner IK, Rana JK, Jänne PA, Eck MJ, Knapp S, Hanke T. Amrhein JA, et al. Among authors: hanke t. J Med Chem. 2022 Dec 8;65(23):15679-15697. doi: 10.1021/acs.jmedchem.2c01041. Epub 2022 Nov 16. J Med Chem. 2022. PMID: 36384036 Free PMC article.

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