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An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity.
Yu D, Wagner S, Schütz M, Jeon Y, Seo M, Kim J, Brückner N, Kicuntod J, Tillmanns J, Wangen C, Hahn F, Kaufer BB, Neipel F, Eickhoff J, Klebl B, Nam K, Marschall M. Yu D, et al. Among authors: marschall m. Pharmaceutics. 2024 Jan 23;16(2):158. doi: 10.3390/pharmaceutics16020158. Pharmaceutics. 2024. PMID: 38399219 Free PMC article.
RICK activates a NF-kappaB-dependent anti-human cytomegalovirus response.
Eickhoff J, Hanke M, Stein-Gerlach M, Kiang TP, Herzberger K, Habenberger P, Müller S, Klebl B, Marschall M, Stamminger T, Cotten M. Eickhoff J, et al. Among authors: marschall m. J Biol Chem. 2004 Mar 5;279(10):9642-52. doi: 10.1074/jbc.M312893200. Epub 2003 Dec 10. J Biol Chem. 2004. PMID: 14670961 Free article.
A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.
Hutterer C, Eickhoff J, Milbradt J, Korn K, Zeitträger I, Bahsi H, Wagner S, Zischinsky G, Wolf A, Degenhart C, Unger A, Baumann M, Klebl B, Marschall M. Hutterer C, et al. Among authors: marschall m. Antimicrob Agents Chemother. 2015 Apr;59(4):2062-71. doi: 10.1128/AAC.04534-14. Epub 2015 Jan 26. Antimicrob Agents Chemother. 2015. PMID: 25624324 Free PMC article.
The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65.
Hutterer C, Niemann I, Milbradt J, Fröhlich T, Reiter C, Kadioglu O, Bahsi H, Zeitträger I, Wagner S, Einsiedel J, Gmeiner P, Vogel N, Wandinger S, Godl K, Stamminger T, Efferth T, Tsogoeva SB, Marschall M. Hutterer C, et al. Among authors: marschall m. Antiviral Res. 2015 Dec;124:101-9. doi: 10.1016/j.antiviral.2015.10.003. Epub 2015 Nov 4. Antiviral Res. 2015. PMID: 26546752
New insight into the phosphorylation-regulated intranuclear localization of human cytomegalovirus pUL69 mediated by cyclin-dependent kinases (CDKs) and viral CDK orthologue pUL97.
Graf L, Feichtinger S, Naing Z, Hutterer C, Milbradt J, Webel R, Wagner S, Scott GM, Hamilton ST, Rawlinson WD, Stamminger T, Thomas M, Marschall M. Graf L, et al. Among authors: marschall m. J Gen Virol. 2016 Jan;97(1):144-151. doi: 10.1099/jgv.0.000337. Epub 2015 Nov 6. J Gen Virol. 2016. PMID: 26555090
232 results