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Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6.
Aguilar EN, Sagar S, Murray BR, Rajesh C, Lei EK, Michaud SA, Goodlett DR, Caffrey TC, Grandgenett PM, Swanson B, Brooks TM, Black AR, van Faassen H, Hussack G, Henry KA, Hollingsworth MA, Brooks CL, Radhakrishnan P. Aguilar EN, et al. Among authors: radhakrishnan p. Mol Cancer Ther. 2024 Feb 23. doi: 10.1158/1535-7163.MCT-23-0868. Online ahead of print. Mol Cancer Ther. 2024. PMID: 38394685
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.
Chaika NV, Gebregiworgis T, Lewallen ME, Purohit V, Radhakrishnan P, Liu X, Zhang B, Mehla K, Brown RB, Caffrey T, Yu F, Johnson KR, Powers R, Hollingsworth MA, Singh PK. Chaika NV, et al. Among authors: radhakrishnan p. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13787-92. doi: 10.1073/pnas.1203339109. Epub 2012 Aug 6. Proc Natl Acad Sci U S A. 2012. PMID: 22869720 Free PMC article.
Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy.
Radhakrishnan P, Bryant VC, Blowers EC, Rajule RN, Gautam N, Anwar MM, Mohr AM, Grandgenett PM, Bunt SK, Arnst JL, Lele SM, Alnouti Y, Hollingsworth MA, Natarajan A. Radhakrishnan P, et al. Clin Cancer Res. 2013 Apr 15;19(8):2025-35. doi: 10.1158/1078-0432.CCR-12-2909. Epub 2013 Feb 26. Clin Cancer Res. 2013. PMID: 23444213 Free PMC article.
A Polymeric Nanogel-Based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer.
Soni KS, Thomas D, Caffrey T, Mehla K, Lei F, O'Connell KA, Sagar S, Lele SM, Hollingsworth MA, Radhakrishnan P, Bronich TK. Soni KS, et al. Among authors: radhakrishnan p. J Pharmacol Exp Ther. 2019 Sep;370(3):894-901. doi: 10.1124/jpet.118.255372. Epub 2019 Jan 25. J Pharmacol Exp Ther. 2019. PMID: 30683666 Free PMC article.
205 results