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Page 1
Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers.
Boje AS, Pekar L, Koep K, Lipinski B, Rabinovich B, Evers A, Gehlert CL, Krohn S, Xiao Y, Krah S, Zaynagetdinov R, Toleikis L, Poetzsch S, Peipp M, Zielonka S, Klausz K. Boje AS, et al. Among authors: gehlert cl. MAbs. 2024 Jan-Dec;16(1):2315640. doi: 10.1080/19420862.2024.2315640. Epub 2024 Feb 19. MAbs. 2024. PMID: 38372053 Free PMC article.
Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells.
Lustig M, Chan C, Jansen JHM, Bräutigam M, Kölling MA, Gehlert CL, Baumann N, Mester S, Foss S, Andersen JT, Bastian L, Sondermann P, Peipp M, Burger R, Leusen JHW, Valerius T. Lustig M, et al. Among authors: gehlert cl. Front Immunol. 2023 Jun 6;14:1178817. doi: 10.3389/fimmu.2023.1178817. eCollection 2023. Front Immunol. 2023. PMID: 37346044 Free PMC article.
Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody.
Gehlert CL, Rahmati P, Boje AS, Winterberg D, Krohn S, Theocharis T, Cappuzzello E, Lux A, Nimmerjahn F, Ludwig RJ, Lustig M, Rösner T, Valerius T, Schewe DM, Kellner C, Klausz K, Peipp M. Gehlert CL, et al. Front Immunol. 2022 Aug 31;13:957874. doi: 10.3389/fimmu.2022.957874. eCollection 2022. Front Immunol. 2022. PMID: 36119088 Free PMC article.
Multifunctional NK Cell-Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release.
Klausz K, Pekar L, Boje AS, Gehlert CL, Krohn S, Gupta T, Xiao Y, Krah S, Zaynagetdinov R, Lipinski B, Toleikis L, Poetzsch S, Rabinovich B, Peipp M, Zielonka S. Klausz K, et al. Among authors: gehlert cl. J Immunol. 2022 Nov 1;209(9):1724-1735. doi: 10.4049/jimmunol.2100970. Epub 2022 Sep 14. J Immunol. 2022. PMID: 36104113
Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis.
Vogiatzi F, Heymann J, Müller K, Winterberg D, Drakul A, Rösner T, Lenk L, Heib M, Gehlert CL, Cario G, Schrappe M, Claviez A, Bornhauser B, Bourquin JP, Bomken S, Adam D, Frielitz FS, Maecker-Kolhoff B, Stanulla M, Valerius T, Peipp M, Kellner C, Schewe DM. Vogiatzi F, et al. Among authors: gehlert cl. Blood Adv. 2022 Aug 23;6(16):4847-4858. doi: 10.1182/bloodadvances.2022007364. Blood Adv. 2022. PMID: 35820018 Free PMC article.
Identification of New Antibodies Targeting Malignant Plasma Cells for Immunotherapy by Next-Generation Sequencing-Assisted Phage Display.
Krohn S, Boje AS, Gehlert CL, Lutz S, Darzentas N, Knecht H, Herrmann D, Brüggemann M, Scheidig AJ, Weisel K, Gramatzki M, Peipp M, Klausz K. Krohn S, et al. Among authors: gehlert cl. Front Immunol. 2022 Jun 17;13:908093. doi: 10.3389/fimmu.2022.908093. eCollection 2022. Front Immunol. 2022. PMID: 35784366 Free PMC article.
Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL.
Müller K, Vogiatzi F, Winterberg D, Rösner T, Lenk L, Bastian L, Gehlert CL, Autenrieb MP, Brüggemann M, Cario G, Schrappe M, Kulozik AE, Eckert C, Bergmann AK, Bornhauser B, Bourquin JP, Valerius T, Peipp M, Kellner C, Schewe DM. Müller K, et al. Among authors: gehlert cl. Blood. 2022 Jul 7;140(1):45-57. doi: 10.1182/blood.2021014485. Blood. 2022. PMID: 35452517 Free article.
Engineering of CD19 Antibodies: A CD19-TRAIL Fusion Construct Specifically Induces Apoptosis in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Cells In Vivo.
Winterberg D, Lenk L, Oßwald M, Vogiatzi F, Gehlert CL, Frielitz FS, Klausz K, Rösner T, Valerius T, Trauzold A, Peipp M, Kellner C, Schewe DM. Winterberg D, et al. Among authors: gehlert cl. J Clin Med. 2021 Jun 15;10(12):2634. doi: 10.3390/jcm10122634. J Clin Med. 2021. PMID: 34203833 Free PMC article.
Affinity Maturation of B7-H6 Translates into Enhanced NK Cell-Mediated Tumor Cell Lysis and Improved Proinflammatory Cytokine Release of Bispecific Immunoligands via NKp30 Engagement.
Pekar L, Klausz K, Busch M, Valldorf B, Kolmar H, Wesch D, Oberg HH, Krohn S, Boje AS, Gehlert CL, Toleikis L, Krah S, Gupta T, Rabinovich B, Zielonka S, Peipp M. Pekar L, et al. Among authors: gehlert cl. J Immunol. 2021 Jan 1;206(1):225-236. doi: 10.4049/jimmunol.2001004. Epub 2020 Dec 2. J Immunol. 2021. PMID: 33268483 Free PMC article.