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Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.
Kai Y, Hikita H, Tatsumi T, Nakabori T, Saito Y, Morishita N, Tanaka S, Nawa T, Oze T, Sakamori R, Yakushijin T, Hiramatsu N, Suemizu H, Takehara T. Kai Y, et al. J Gastroenterol. 2015 Nov;50(11):1145-51. doi: 10.1007/s00535-015-1108-6. Epub 2015 Jul 25. J Gastroenterol. 2015. PMID: 26208695
Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment.
Kai Y, Hikita H, Morishita N, Murai K, Nakabori T, Iio S, Hagiwara H, Imai Y, Tamura S, Tsutsui S, Naito M, Nishiuchi M, Kondo Y, Kato T, Suemizu H, Yamada R, Oze T, Yakushijin T, Hiramatsu N, Sakamori R, Tatsumi T, Takehara T. Kai Y, et al. Sci Rep. 2017 Jan 30;7:41660. doi: 10.1038/srep41660. Sci Rep. 2017. PMID: 28134353 Free PMC article.
DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway.
Saito Y, Hikita H, Nozaki Y, Kai Y, Makino Y, Nakabori T, Tanaka S, Yamada R, Shigekawa M, Kodama T, Sakamori R, Tatsumi T, Takehara T. Saito Y, et al. Among authors: kai y. Cell Death Differ. 2019 Mar;26(3):470-486. doi: 10.1038/s41418-018-0131-6. Epub 2018 May 31. Cell Death Differ. 2019. PMID: 29855540 Free PMC article.
Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice.
Doi A, Hikita H, Kai Y, Tahata Y, Saito Y, Nakabori T, Yamada R, Kodama T, Sakamori R, Murayama A, Nitta S, Asahina Y, Suemizu H, Tatsumi T, Kato T, Takehara T. Doi A, et al. Among authors: kai y. J Gastroenterol. 2019 May;54(5):449-458. doi: 10.1007/s00535-018-01541-x. Epub 2019 Jan 25. J Gastroenterol. 2019. PMID: 30684016
Water-slider method reduced colonic polyp fragmentation compared with conventional suction retrieval: A prospective randomized controlled study.
Shimayoshi A, Bessho H, Kawamoto Y, Yamamoto S, Sung J, Morita Y, Wakamatsu S, Horie M, Kai Y, Takeda R, Iwahashi K, Shibukawa N, Miyazaki M, Egawa S, Oshita M. Shimayoshi A, et al. Among authors: kai y. Dig Liver Dis. 2021 Jun;53(6):717-721. doi: 10.1016/j.dld.2020.12.116. Epub 2021 Jan 18. Dig Liver Dis. 2021. PMID: 33478875 Clinical Trial.
843 results