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Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J Med Chem. 2024 Mar 14;67(5):3935-3958. doi: 10.1021/acs.jmedchem.3c02248. Epub 2024 Feb 16.
J Med Chem. 2024.
PMID: 38365209
Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.
Fox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S.
Fox NG, et al.
Nat Commun. 2019 May 17;10(1):2210. doi: 10.1038/s41467-019-09989-y.
Nat Commun. 2019.
PMID: 31101807
Free PMC article.
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4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function.
Majmudar JD, Feng X, Fox NG, Nabhan JF, Towle T, Ma T, Gooch R, Bulawa C, Yue WW, Martelli A.
Majmudar JD, et al. Among authors: fox ng.
Medchemcomm. 2019 Jan 8;10(2):209-220. doi: 10.1039/c8md00489g. eCollection 2019 Feb 1.
Medchemcomm. 2019.
PMID: 30881609
Free PMC article.
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Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.
Fox NG, Martelli A, Nabhan JF, Janz J, Borkowska O, Bulawa C, Yue WW.
Fox NG, et al.
Biochimie. 2018 Sep;152:211-218. doi: 10.1016/j.biochi.2018.07.012. Epub 2018 Jul 20.
Biochimie. 2018.
PMID: 30031876
Free PMC article.
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Frataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe-S Assembly Complex.
Fox NG, Das D, Chakrabarti M, Lindahl PA, Barondeau DP.
Fox NG, et al.
Biochemistry. 2015 Jun 30;54(25):3880-9. doi: 10.1021/bi5014497. Epub 2015 Jun 18.
Biochemistry. 2015.
PMID: 26016518
Free PMC article.
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The Human Iron-Sulfur Assembly Complex Catalyzes the Synthesis of [2Fe-2S] Clusters on ISCU2 That Can Be Transferred to Acceptor Molecules.
Fox NG, Chakrabarti M, McCormick SP, Lindahl PA, Barondeau DP.
Fox NG, et al.
Biochemistry. 2015 Jun 30;54(25):3871-9. doi: 10.1021/bi5014485. Epub 2015 Jun 12.
Biochemistry. 2015.
PMID: 26016389
Free PMC article.
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Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry.
Bridwell-Rabb J, Fox NG, Tsai CL, Winn AM, Barondeau DP.
Bridwell-Rabb J, et al. Among authors: fox ng.
Biochemistry. 2014 Aug 5;53(30):4904-13. doi: 10.1021/bi500532e. Epub 2014 Jul 18.
Biochemistry. 2014.
PMID: 24971490
Free PMC article.
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Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.
Meier MM, Rajendran C, Malisi C, Fox NG, Xu C, Schlee S, Barondeau DP, Höcker B, Sterner R, Raushel FM.
Meier MM, et al. Among authors: fox ng.
J Am Chem Soc. 2013 Aug 7;135(31):11670-7. doi: 10.1021/ja405911h. Epub 2013 Jul 29.
J Am Chem Soc. 2013.
PMID: 23837603
Free PMC article.
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