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Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors.
Santofimia-Castaño P, Fraunhoffer N, Liu X, Bessone IF, di Magliano MP, Audebert S, Camoin L, Estaras M, Brenière M, Modesti M, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J. Santofimia-Castaño P, et al. Among authors: breniere m. EMBO Mol Med. 2024 Mar;16(3):475-505. doi: 10.1038/s44321-024-00032-2. Epub 2024 Feb 15. EMBO Mol Med. 2024. PMID: 38360999 Free PMC article.
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro.
Vu DD, Bonucci A, Brenière M, Cisneros-Aguirre M, Pelupessy P, Wang Z, Carlier L, Bouvignies G, Cortes P, Aggarwal AK, Blackledge M, Gueroui Z, Belle V, Stark JM, Modesti M, Ferrage F. Vu DD, et al. Among authors: breniere m. bioRxiv [Preprint]. 2023 Jul 13:2023.07.12.548668. doi: 10.1101/2023.07.12.548668. bioRxiv. 2023. PMID: 37503201 Free PMC article. Preprint.
Catalytically inactive DNA ligase IV promotes DNA repair in living cells.
Goff NJ, Brenière M, Buehl CJ, de Melo AJ, Huskova H, Ochi T, Blundell TL, Mao W, Yu K, Modesti M, Meek K. Goff NJ, et al. Among authors: breniere m. Nucleic Acids Res. 2022 Oct 28;50(19):11058-11071. doi: 10.1093/nar/gkac913. Nucleic Acids Res. 2022. PMID: 36263813 Free PMC article.