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Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state.
Voshart DC, Oshima T, Jiang Y, van der Linden GP, Ainslie AP, Reali Nazario L, van Buuren-Broek F, Scholma AC, van Weering HRJ, Brouwer N, Sewdihal J, Brouwer U, Coppes RP, Holtman IR, Eggen BJL, Kooistra SM, Barazzuol L. Voshart DC, et al. Among authors: brouwer n. Cell Rep. 2024 Feb 27;43(2):113764. doi: 10.1016/j.celrep.2024.113764. Epub 2024 Feb 14. Cell Rep. 2024. PMID: 38358885 Free article.
Epigenetic regulation of innate immune memory in microglia.
Zhang X, Kracht L, Lerario AM, Dubbelaar ML, Brouwer N, Wesseling EM, Boddeke EWGM, Eggen BJL, Kooistra SM. Zhang X, et al. Among authors: brouwer n. J Neuroinflammation. 2022 May 14;19(1):111. doi: 10.1186/s12974-022-02463-5. J Neuroinflammation. 2022. PMID: 35568856 Free PMC article.
Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening.
Raj DD, Moser J, van der Pol SM, van Os RP, Holtman IR, Brouwer N, Oeseburg H, Schaafsma W, Wesseling EM, den Dunnen W, Biber KP, de Vries HE, Eggen BJ, Boddeke HW. Raj DD, et al. Among authors: brouwer n. Aging Cell. 2015 Dec;14(6):1003-13. doi: 10.1111/acel.12370. Epub 2015 Aug 3. Aging Cell. 2015. PMID: 26238505 Free PMC article.
Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease.
Yin Z, Raj D, Saiepour N, Van Dam D, Brouwer N, Holtman IR, Eggen BJL, Möller T, Tamm JA, Abdourahman A, Hol EM, Kamphuis W, Bayer TA, De Deyn PP, Boddeke E. Yin Z, et al. Among authors: brouwer n. Neurobiol Aging. 2017 Jul;55:115-122. doi: 10.1016/j.neurobiolaging.2017.03.021. Epub 2017 Mar 27. Neurobiol Aging. 2017. PMID: 28434692
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease.
Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM. Gerrits E, et al. Among authors: brouwer n. Acta Neuropathol. 2021 May;141(5):681-696. doi: 10.1007/s00401-021-02263-w. Epub 2021 Feb 20. Acta Neuropathol. 2021. PMID: 33609158 Free PMC article.
149 results